ArticleJournal of molecular biology2010
A survey of lambda repressor fragments from two-state to downhill folding.
Article in Journal of molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- DreamFold: A World Model to efficiently generate protein folding pathways in the latent space.Protein science : a publication of the Protein Society · 2026Article
- Incomplete lytic cycle of a widespread Bacteroides bacteriophage leads to the formation of defective viral particles.PLoS biology · 2025Article
- A genome-wide cytotoxicity screen of cluster F1 mycobacteriophage Girr reveals novel inhibitors of Mycobacterium smegmatis growth.G3 (Bethesda, Md.) · 2024Article
- Fast pressure-jump all-atom simulations and experiments reveal site-specific protein dehydration-folding dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Co-translational folding of α-helical proteins: structural studies of intermediate-length variants of the λ repressor.FEBS open bio · 2018Article
- The Surface of Protein λBiochemistry · 2017Article
- How cooperative are protein folding and unfolding transitions?Protein science : a publication of the Protein Society · 2016Review
- Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Sequence, structure, and cooperativity in folding of elementary protein structural motifs.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mapping fast protein folding with multiple-site fluorescent probes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Fast protein folding kinetics.Quarterly reviews of biophysics · 2014Review
- Observation of complete pressure-jump protein refolding in molecular dynamics simulation and experiment.Journal of the American Chemical Society · 2014Article
- Engineering folding dynamics from two-state to downhill: application to λ-repressor.The journal of physical chemistry. B · 2013Article
- Dodine as a protein denaturant: the best of two worlds?The journal of physical chemistry. B · 2013Article
- Misplaced helix slows down ultrafast pressure-jump protein folding.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Discrete molecular dynamics: an efficient and versatile simulation method for fine protein characterization.The journal of physical chemistry. B · 2012Article
- Equilibrium unfolding of the PDZ domain of β2-syntrophin.Biophysical journal · 2012Article
- Structural Characterization of λ-Repressor Folding from All-Atom Molecular Dynamics Simulations.The journal of physical chemistry letters · 2012Article
- Crowding effects on the small, fast-folding protein lambda6-85.Faraday discussions · 2012Article
- The fast and the slow: folding and trapping of λ6-85.Journal of the American Chemical Society · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We survey the two-state to downhill folding transition by examining 20 lambda(6-85)* mutants that cover a wide range of stabilities and folding rates. We investigated four new lambda(6-85)* mutants designed to fold especially rapidly. Two were engineered using the core remodeling of Lim and Sauer, and two were engineered using Ferreiro et al.'s frustratometer. These proteins have probe-dependent melting temperatures as high as 80 degrees C and exhibit a fast molecular phase with the characteristic temperature dependence of the amplitude expected for downhill folding. The survey reveals a correlation between melting temperature and downhill folding previously observed for the beta-sheet protein WW domain. A simple model explains this correlation and predicts the melting temperature at which downhill folding becomes possible. An X-ray crystal structure with a 1.64-A resolution of a fast-folding mutant fragment shows regions of enhanced rigidity compared to the full wild-type protein.
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Registered trials
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