ArticleExperimental parasitology2010
Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice.
Article in Experimental parasitology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Malaria Related Neurocognitive Deficits and Behavioral Alterations.Frontiers in cellular and infection microbiology · 2022Review
- Embryonic Stage of Congenital Zika Virus Infection Determines Fetal and Postnatal Outcomes in Mice.Viruses · 2021Article
- Article
- KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.Scientific reports · 2019Article
- Inhibition of hypoxia-associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria.Journal of neuroinflammation · 2018Article
- A Neuroprotective Effect of the Glutamate Receptor Antagonist MK801 on Long-Term Cognitive and Behavioral Outcomes Secondary to Experimental Cerebral Malaria.Molecular neurobiology · 2017Article
- Behavioural and neurological symptoms accompanied by cellular neuroinflammation in IL-10-deficient mice infected with Plasmodium chabaudi.Malaria journal · 2016Article
- Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria.Malaria journal · 2015Article
- Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?Clinical microbiology reviews · 2015Review
- Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.PLoS pathogens · 2014Article
- Imaging Plasmodium immunobiology in the liver, brain, and lung.Parasitology international · 2014Review
- Experimental Models of Microvascular Immunopathology: The Example of Cerebral Malaria.Journal of neuroinfectious diseases · 2014Article
- Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria.Malaria journal · 2013Article
- Neuroimmunological blood brain barrier opening in experimental cerebral malaria.PLoS pathogens · 2012Article
- Interleukin-18 Antagonism Improved Histopathological Conditions of Malaria Infection in Mice.Iranian journal of parasitologyArticle
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Experimental cerebral malaria is a neuroinflammatory condition that results from the host immune response to the parasite. Using intravital microscopy, we investigated leukocyte recruitment in the brain microcirculation and the temporal relationship of this process to the behavioral changes observed in Plasmodium berghei (strain ANKA)-infected C57Bl/6 mice. We found that leukocyte recruitment was increased from day 5 post-infection (p.i.) onwards. Histopathological changes and increased levels of inflammatory cytokines in the brain were also observed. Behavioral performance evaluated by the SHIRPA protocol showed functional impairment from day 6 p.i. onwards. Thus, early leukocyte migration into the brain and associated inflammatory changes may be involved in neurological impairment in parasite-infected C57Bl/6 mice.
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