ArticleAtherosclerosis2010
Longitudinal association between toenail selenium levels and measures of subclinical atherosclerosis: the CARDIA trace element study.
Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials.European journal of clinical nutrition · 2016Pooled it
- Association of Serum Selenium with Pro-Atherogenic Adhesion Molecules, Inflammatory Cytokines and Carotid Intima-Media Thickness in Patients with Metabolic Syndrome.Biological trace element research · 2026Article
- Urban imperviousness and carotid intima-medial thickness: Evidence from the Coronary Artery Risk Development in Young Adults (CARDIA) study.The Science of the total environment · 2025Article
- Temperature and carotid intima-medial thickness: The coronary artery risk development in young adults (CARDIA) study.The Science of the total environment · 2024Article
- Crucial Interactions between Altered Plasma Trace Elements and Fatty Acids Unbalance Ratio to Management of Systemic Arterial Hypertension in Diabetic Patients: Focus on Endothelial Dysfunction.International journal of molecular sciences · 2024Article
- Estimation of elemental concentrations in the toenail of young Saudi females with obesity.Journal of medicine and life · 2022Article
- Long-chain omega-3 fatty acids, selenium, and mercury in relation to sleep duration and sleep quality: findings from the CARDIA study.European journal of nutrition · 2022Article
- Association between toenail zinc concentrations and incidence of asthma among American young adults: The CARDIA study.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021Article
- The Total Antioxidant Status, Serum Selenium Concentrations and the Ultrasound Assessment Carotid Intima Media Thickness in Patients with Arterial Hypertension.Antioxidants (Basel, Switzerland) · 2021Article
- The Association Between Dietary Antioxidant Micronutrients and Cardiovascular Disease in Adults in the United States: A Cross-Sectional Study.Frontiers in nutrition · 2021Article
- Toenails as biomarker of exposure to essential trace metals: A review.Environmental research · 2019Review
- Selenium and large artery structure and function: a 10-year prospective study.European journal of nutrition · 2019Article
- Investigation of Trace Elements in the Hair and Nail of Patients with Stomach Cancer.Indian journal of clinical biochemistry : IJCB · 2018Article
- Longitudinal association between toenail zinc levels and the incidence of diabetes among American young adults: The CARDIA Trace Element Study.Scientific reports · 2016Article
- Review
- Selenium toxicity from a misformulated dietary supplement, adverse health effects, and the temporal response in the nail biologic monitor.Nutrients · 2013Article
- Increased hair selenium concentration in hyperlipidemic patients.Journal of cellular and molecular medicine · 2013Article
- Article
- Fish oil, selenium and mercury in relation to incidence of hypertension: a 20-year follow-up study.Journal of internal medicine · 2011Article
- Distribution of toenail selenium levels in young adult Caucasians and African Americans in the United States: the CARDIA Trace Element Study.Environmental research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo examine the longitudinal association between toenail selenium levels and subclinical atherosclerosis over an 18-year period.
methodsToenail selenium concentrations were examined among 3112 Americans age 20-32 years in 1987 and measured by instrumental neutron-activation analysis. Subclinical atherosclerosis, including common, bulb and internal carotid intima-media thickness (CIMT), was measured in 2005 and coronary artery calcium (CAC) score in 2000 and 2005. General linear regression was developed examining the relation between toenail selenium levels and CIMTs, and logistic regression for repeated outcomes was employed estimating the risk of having CAC>0.
resultsAfter adjustment for potential confounders, no associations were observed between toenail selenium levels and CIMTs as well as CAC score. Comparing participants in the highest with the lowest quintile of selenium, the CIMT was 0.005 mm (SE=0.008 mm, Ptrend=0.39), 0.018 mm (SE=0.019 mm, Ptrend=0.49), and 0.017 mm (SE=0.014 mm, Ptrend=0.21) thicker measured in common, bulb and internal carotid, respectively. The adjusted odds ratio of having CAC>0 was 0.95 (95% CI: 0.67-1.35; Ptrend=0.999).
conclusionsNo associations were observed between toenail selenium and measures of subclinical atherosclerosis among American young adults. This study does not support an atherosclerotic mechanism of selenium for risk reduction of cardiovascular disease.
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