ReviewCurrent opinion in structural biology2010
Understanding biology by stretching proteins: recent progress.
Review in Current opinion in structural biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Mechanical Behavior of Octopus Egg Tethers Composed of Topologically Constrained, Tandemly Repeated EGF Domains.Biomacromolecules · 2023Article
- Mechanical Stability of a Small, Highly-Luminescent Engineered Protein NanoLuc.International journal of molecular sciences · 2020Article
- Nanomechanics of tip-link cadherins.Scientific reports · 2019Article
- Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins.Cardiovascular research · 2018Article
- Unusually high mechanical stability of bacterial adhesin extender domains having calcium clamps.PloS one · 2017Article
- Effects of ligand binding on the mechanical stability of protein GB1 studied by steered molecular dynamics simulation.Journal of molecular modeling · 2016Article
- The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins.Nature communications · 2015Article
- Nanomechanics of β-rich proteins related to neuronal disorders studied by AFM, all-atom and coarse-grained MD methods.Journal of molecular modeling · 2014Article
- The effect of tensile stress on the conformational free energy landscape of disulfide bonds.PloS one · 2014Article
- Article
- Single-molecule studies on PolySUMO proteins reveal their mechanical flexibility.Biophysical journal · 2013Article
- Tracking unfolding and refolding reactions of single proteins using atomic force microscopy methods.Methods (San Diego, Calif.) · 2013Article
- Formation of cystine slipknots in dimeric proteins.PloS one · 2013Article
- Single-molecule experiments reveal the flexibility of a Per-ARNT-Sim domain and the kinetic partitioning in the unfolding pathway under force.Biophysical journal · 2012Article
- Engineering proteins with enhanced mechanical stability by force-specific sequence motifs.Proteins · 2012Article
- End-to-end attraction of duplex DNA.Nucleic acids research · 2012Article
- Dynamics of protein folding and cofactor binding monitored by single-molecule force spectroscopy.Biophysical journal · 2011Article
- Ligand-modulated parallel mechanical unfolding pathways of maltose-binding proteins.The Journal of biological chemistry · 2011Article
- Protein folding at single-molecule resolution.Biochimica et biophysica acta · 2011Review
- Molecular dynamics-based simulation of trace amine membrane permeability.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Single molecule manipulation techniques combined with molecular dynamics simulations and protein engineering have enabled, during the last decade, the mechanical properties of proteins to be studied directly, thereby giving birth to the field of protein nanomechanics. Recent data obtained from such techniques have helped gain insight into the structural bases of protein resistance against forced unfolding, as well as revealing structural motifs involved in mechanical stability. Also, important technical developments have provided new perspectives into protein folding. Eventually, new and exciting data have shown that mechanical properties are key factors in cell signaling and pathologies, and have been used to rationally tune these properties in a variety of proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.