ArticleGastroenterology2010
Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.
Article in Gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
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Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it, 188 citations in OpenAlex.
- In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection.PLoS pathogens · 2020Pooled it
- Akkermansia muciniphila supplementation alters inflammatory profiles across diverse models of colitis.Scientific reports · 2026Article
- Large neutral amino acid uptake and mTOR activation within CD4 T cells coordinate type 2 immunity and host resistance toDiscovery immunology · 2026Article
- Infection with gut parasites correlates with gut microbiome diversity across human populations in Africa.Gut microbes · 2025Article
- Mucins and Their Roles in Asthma.Immunological reviews · 2025Review
- Microphysiological gut-on-chip enables extendedFrontiers in cellular and infection microbiology · 2025Article
- A Small Intestinal Helminth Infection Alters Colonic Mucus and Shapes the Colonic Mucus Microbiome.International journal of molecular sciences · 2024Article
- Sea Buckthorn Polysaccharide Ameliorates Colitis.Nutrients · 2024Article
- Unraveling the gut: the pivotal role of intestinal mechanisms in Kawasaki disease pathogenesis.Frontiers in immunology · 2024Review
- Production of Intestinal Mucins, sIgA, and Metallothionein after Administration of Zinc and Infection ofLife (Basel, Switzerland) · 2022Article
- The Cysteine Protease Giardipain-1 fromInternational journal of molecular sciences · 2022Article
- Mucins and CFTR: Their Close Relationship.International journal of molecular sciences · 2022Review
- Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.Mucosal immunology · 2022Article
- Tissue-specific immunity in helminth infections.Mucosal immunology · 2022Review
- "Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity".Mucosal immunology · 2022Review
- Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminthFrontiers in immunology · 2022Article
- A Chinese herbs complex ameliorates gut microbiota dysbiosis induced by intermittent cold exposure in female rats.Frontiers in microbiology · 2022Article
- Mucus and Mucins: The Underappreciated Host Defence System.Frontiers in cellular and infection microbiology · 2022Review
- Gut Microbiota and Dietary Factors as Modulators of the Mucus Layer in Inflammatory Bowel Disease.International journal of molecular sciences · 2021Review
- Review
42 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
BACKGROUND &
aimsHyperplasia of mucin-secreting intestinal goblet cells accompanies a number of enteric infections, including infections by nematode parasites. Nevertheless, the precise role of mucins in host defense in nematode infection is not known. We investigated the role of the mucin (Muc2) in worm expulsion and host immunity in a model of nematode infection.
methodsResistant (BALB/c, C57BL/6), susceptible (AKR), and Muc2-deficient mouse strains were infected with the nematode, Trichuris muris, and worm expulsion, energy status of the whipworms, changes in mucus/mucins, and inflammatory and immune responses were investigated after infection.
resultsThe increase in Muc2 production, observed exclusively in resistant mice, correlated with worm expulsion. Moreover, expulsion of the worms from the intestine was significantly delayed in the Muc2-deficient mice. Although a marked impairment in the development of periodic acid Schiff (PAS)-stained intestinal goblet cells was observed in Muc2-deficient mice, as infection progressed a significant increase in the number of PAS-positive goblet cells was observed in these mice. Surprisingly, an increase in Muc5ac, a mucin normally expressed in the airways and stomach, was observed after infection of only the resistant animals. Overall, the mucus barrier in the resistant mice was less permeable than that of susceptible mice. Furthermore, the worms isolated from the resistant mice had a lower energy status.
conclusionsMucins are an important component of innate defense in enteric infection; this is the first demonstration of the important functional contribution of mucins to host protection from nematode infection.
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