ArticleBMC veterinary research2010
The prevalence of atypical scrapie in sheep from positive flocks is not higher than in the general sheep population in 11 European countries.
Article in BMC veterinary research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 46 citations in OpenAlex.
- Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Impact of Removing the Monitoring Requirements for Holdings with Atypical Scrapie in Great Britain.Animals : an open access journal from MDPI · 2024Article
- Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease.Veterinary research · 2023Article
- A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants.PLoS pathogens · 2022Article
- Chronic wasting disease in Europe: new strains on the horizon.Acta veterinaria Scandinavica · 2021Review
- Scientific report on the analysis of the 2-year compulsory intensified monitoring of atypical scrapie.EFSA journal. European Food Safety Authority · 2021Article
- The emergence of classical BSE from atypical/Nor98 scrapie.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Animal prion diseases: the risks to human health.Brain pathology (Zurich, Switzerland) · 2019Review
- Using an epidemiological framework and bovine spongiform encephalopathy investigation questionnaire to investigate suspect bovine spongiform encephalopathy cases: an example from a bovine spongiform encephalopathy case in Ireland in 2015.The Veterinary record · 2018Article
- Pathology of Animal Transmissible Spongiform Encephalopathies (TSEs).Food safety (Tokyo, Japan) · 2017Review
- Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic.Journal of applied genetics · 2017Article
- Chronic wasting disease (CWD) in cervids.EFSA journal. European Food Safety Authority · 2017Article
- Epidemiological investigations on the potential transmissibility of a rare disease: the case of atypical scrapie in Great Britain.Epidemiology and infection · 2016Article
- Review
- Cytosolic PrP can participate in prion-mediated toxicity.Journal of virology · 2014Article
- Genetic resistance to scrapie infection in experimentally challenged goats.Journal of virology · 2014Article
- Clinical examination protocol to detect atypical and classical scrapie in sheep.Journal of visualized experiments : JoVE · 2014Article
- Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.BioMed research international · 2014Article
- Article
- Genotyping and surveillance for scrapie in Finnish sheep.BMC veterinary research · 2012Article
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Authors and funding
12 authors at 7 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the last decade, active surveillance for transmissible spongiform encephalopathies in small ruminants has been intensive in Europe. In many countries this has led to the detection of cases of atypical scrapie which, unlike classical scrapie, might not be contagious. EU legislation requires, that following detection of a scrapie case, control measures including further testing take place in affected flocks, including the culling of genotype susceptible to classical scrapie. This might result in the detection of additional cases. The aim of this study was to investigate the occurrence of additional cases in flocks affected by atypical scrapie using surveillance data collected in Europe in order to ascertain whether atypical scrapie, is contagious.
resultsQuestionnaires were used to collect, at national level, the results of active surveillance and testing associated with flock outbreaks in 12 European countries. The mean prevalence of atypical scrapie was 5.5 (5.0-6.0) cases per ten thousand in abattoir surveillance and 8.1 (7.3-9.0) cases per ten thousand in fallen stock. By using meta-analysis, on 11 out of the 12 countries, we found that the probability of detecting additional cases of atypical scrapie in positive flocks was similar to the probability observed in animals slaughtered for human consumption (odds ratio, OR = 1.07, CI95%: 0.70-1.63) or among fallen stock (OR = 0.78, CI95%: 0.51-1.2). In contrast, when comparing the two scrapie types, the probability of detecting additional cases in classical scrapie positive flocks was significantly higher than the probability of detecting additional cases in atypical scrapie positive flocks (OR = 32.4, CI95%: 20.7-50.7).
conclusionsThese results suggest that atypical scrapie is not contagious or has a very low transmissibility under natural conditions compared with classical scrapie. Furthermore this study stressed the importance of standardised data collection to make good use of the analyses undertaken by European countries in their efforts to control atypical and classical scrapie.
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