Evidence map›Paper›PMID 20136736›Full record

ReviewRespirology (Carlton, Vic.)2010

Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions.

Peter R Eastwood, Atul Malhotra, Lyle J Palmer, Eric J Kezirian, Richard L Horner, Mary S Ip, Robert Thurnheer, Nick A Antic, David R Hillman

Abstract readReview
In one paragraph

Review in Respirology (Carlton, Vic.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Effects of Particulate Matter on Obstructive Sleep Apnea and Obesity.Journal of rhinology : official journal of the Korean Rhinologic Society · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Obstructive sleep apnea treatment in adults.The Kaohsiung journal of medical sciences · 2020
    Review
  17. Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test.International journal of environmental research and public health · 2019
    Article
  18. Article
  19. Glucocorticoid Treatment of Symptomatic Sarcoidosis in 2 Morbidly Obese Patients.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2019
    Article
  20. Predicting Success of Oral Appliance Therapy in Treating Obstructive Sleep Apnea Using Drug-Induced Sleep Endoscopy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter R EastwoodWest Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia. peter.eastwood@health.wa.gov.au
Atul Malhotra
Lyle J Palmer
Eric J Kezirian
Richard L Horner
Mary S Ip
Robert Thurnheer
Nick A Antic
David R Hillman

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Mechanisms Underlying the Aging Predisposition to Obstructive Sleep ApneaR01HL090897 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MALHOTRA, ATUL · 2009 to 2012
$1.8M
Sleep Apnea and Obesity: Cardiovascular Risk AssessmentR01HL073146 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MALHOTRA, ATUL · 2003 to 2008
$1.6M
Assessment of Upper Airway Mechanics Using Newer EMG TechniquesK24HL093218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2009 to 2013
$857k
CIHRNCRR NIH HHS KL2 RR024130NHLBI NIH HHS K24 HL 093218NHLBI NIH HHS K24 HL093218NHLBI NIH HHS R01 HL073146NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL090897NHLBI NIH HHS R01 HL73146
6 · The paper itself

Abstract

Obstructive sleep apnoea (OSA) is a common disease, recognized as an independent risk factor for a range of clinical conditions, such as hypertension, stroke, depression and diabetes. Despite extensive research over the past two decades, the mechanistic links between OSA and other associated clinical conditions, including metabolic disorders and cardiovascular disease, remain unclear. Indeed, the pathogenesis of OSA itself remains incompletely understood. This review provides opinions from a number of leading experts on issues related to OSA and its pathogenesis, interaction with anaesthesia, metabolic consequences and comorbidities, cardiovascular disease, genetics, measurement and diagnosis, surgical treatment and pharmacotherapeutic targets.

Indexed as

AnesthesiaCardiovascular DiseasesComorbidityDiabetes MellitusFemaleHumansHypertensionMaleMiddle AgedSleep Apnea, ObstructiveStroke

Identifiers

PMID20136736
PMCPMC4342116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.