ArticleJournal of neuroendocrinology2010
Neonatal programming by neuroimmune challenge: effects on responses and tolerance to septic doses of lipopolysaccharide in adult male and female rats.
Article in Journal of neuroendocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Long-Lasting Impact of Maternal Immune Activation and Interaction With a Second Immune Challenge on Pig Behavior.Frontiers in veterinary science · 2020Article
- Lifetime Modulation of the Pain SystemFrontiers in immunology · 2017Review
- Review: Puberty as a time of remodeling the adult response to ovarian hormones.The Journal of steroid biochemistry and molecular biology · 2016Review
- Enduring influence of pubertal stressors on behavioral response to hormones in female mice.Hormones and behavior · 2013Review
- Carotid chemoreceptor development in mice.Respiratory physiology & neurobiology · 2013Review
- Sex effects on neurodevelopmental outcomes of innate immune activation during prenatal and neonatal life.Hormones and behavior · 2012Review
- Sexually dimorphic effects of a prenatal immune challenge on social play and vasopressin expression in juvenile rats.Biology of sex differences · 2012Article
- Nutritionally mediated programming of the developing immune system.Advances in nutrition (Bethesda, Md.) · 2011Review
- Neonatal programming of innate immune function.American journal of physiology. Endocrinology and metabolism · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A mild immune challenge experienced during the neonatal period leads to attenuated febrile responses to a similar challenge experienced later in life. However, the immune response to an endotoxin differs depending upon the severity of the challenge and it is not clear whether a neonatal immune challenge will also affect responses to a severe, potentially life-threatening stimulus, such as sepsis. In the present study, we examined the effects of a neonatal immune challenge with lipopolysaccharide (LPS) on adult sickness responses, as well as the development of endotoxin tolerance, to a septic dose (1 or 3 mg/kg) of the same LPS in male and female rats. We demonstrate significant differences, particularly in males, in the fever profiles of neonatally LPS-treated rats compared to neonatally saline-treated controls. Specifically, male rats treated neonatally with LPS have reduced hypothermic and enhanced hyperthermic responses to both septic doses of LPS in adulthood. A somewhat different profile is seen in females, with neonatally LPS-treated females having reduced hypothermia and enhanced hyperthermia compared to controls with 1 mg/kg but no differences with 3 mg/kg LPS. The results obtained demonstrate that alterations in innate immune responses previously reported for low doses of LPS can, for the most part, also be observed after severe immune challenge in later life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.