ArticleThe Journal of infectious diseases2010
A piglet model of acute gastroenteritis induced by Shigella dysenteriae Type 1.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Probiotic Bacillus licheniformis DSMZ 28710 improves sow milk microbiota and enhances piglet health outcomes.Scientific reports · 2025Article
- Epithelial Cell Infection Analyses with Shigella.Journal of visualized experiments : JoVE · 2024Article
- An Experimental Adult Zebrafish Model forMicrobiology spectrum · 2022Article
- Article
- Impact of the Lipopolysaccharide Chemotype ofToxins · 2019Article
- Human Intestinal Enteroids as a Model System ofInfection and immunity · 2019Article
- Colonization of preterm gnotobiotic piglets with probiotic Lactobacillus rhamnosus GG and its interference with Salmonella Typhimurium.Clinical and experimental immunology · 2019Article
- Article
- The piglet acute diarrhea model for evaluating efficacy of treatment and control of cryptosporidiosis.Human vaccines & immunotherapeutics · 2019Article
- The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis.PloS one · 2017Article
- Review
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- Pathogenicity of Shigella in chickens.PloS one · 2014Article
- Article
- Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells.Journal of microbiology (Seoul, Korea) · 2013Review
- Article
- Shiga toxin-producing Escherichia coli O104:H4: a new challenge for microbiology.Applied and environmental microbiology · 2012Review
- In vivo versus in vitro protein abundance analysis of Shigella dysenteriae type 1 reveals changes in the expression of proteins involved in virulence, stress and energy metabolism.BMC microbiology · 2011Article
- A bovine lactoferricin-lactoferrampin-encodingGut microbesArticle
- A pig model of the human gastrointestinal tract.Gut microbesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe lack of a standardized laboratory animal model that mimics key aspects of human shigellosis remains a major obstacle to addressing questions about pathogenesis, screening therapeutics, and evaluation of vaccines.
methodsWe characterized a piglet model for Shigella dysenteriae type 1.
resultsPiglets developed acute diarrhea, anorexia, and dehydration, which could often be fatal, with symptom severity depending on age and dose. Bacteria were apparent in the lumen and on the surface epithelium throughout the gut initially, but severe mucosal damage and bacterial cellular invasion were most profound in the colon. Detached necrotic colonocytes were present in the lumen, with inflammatory cells outpouring from damaged mucosa. High levels of interleukin (IL)-8 and IL-12 were followed by high levels of other proinflammatory cytokines. Elevated levels of tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-10 were detected in feces and in gut segments from infected animals. Bacteria were present inside epithelial cells and within colonic lamina propria. In contrast, an isogenic strain lacking Shiga toxin induced similar but milder symptoms, with moderate mucosal damage and lower cytokine levels.
conclusionWe conclude that piglets are highly susceptible to shigellosis, providing a useful tool with which to compare vaccine candidates for immunogenicity, reactogenicity, and response to challenge; investigate the role of virulence factors; and test the efficacy of microbial agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.