ArticleBehavior genetics2010
Neonatal maternal separation alters immune, endocrine, and behavioral responses to acute Theiler's virus infection in adult mice.
Article in Behavior genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms.International journal of molecular sciences · 2024Review
- The Relationship of Family Functioning and Suicidal Ideation among Adolescents: The Mediating Role of Defeat and the Moderating Role of Meaning in Life.International journal of environmental research and public health · 2022Article
- Article
- Positive Correlation between nNOS and Stress-Activated Bowel Motility Is Confirmed by In Vivo HiBiT System.Cells · 2021Article
- Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling.Nature communications · 2021Article
- Maternal separation leads to regional hippocampal microglial activation and alters the behavior in the adolescence in a sex-specific manner.Brain, behavior, & immunity - health · 2020Article
- Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies.Scientific reports · 2020Article
- Neonatal corticosterone mitigates autoimmune neuropsychiatric disorders associated with streptococcus in mice.Scientific reports · 2018Article
- Modulating the Oxytocin System During the Perinatal Period: A New Strategy for Neuroprotection of the Immature Brain?Frontiers in neurology · 2018Review
- Host genetic background influences diverse neurological responses to viral infection in mice.Scientific reports · 2017Article
- Neonatal corticosterone administration in rodents as a tool to investigate the maternal programming of emotional and immune domains.Neurobiology of stress · 2017Article
- Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines.Psychoneuroendocrinology · 2016Article
- Pediatric Autoimmune Disorders Associated with Streptococcal Infections and Tourette's Syndrome in Preclinical Studies.Frontiers in neuroscience · 2016Review
- Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood.Acta physiologica (Oxford, England) · 2014Review
- Environmental factors acting during development to influence MS risk: insights from animal studies.Multiple sclerosis (Houndmills, Basingstoke, England) · 2013Review
- Maternal separation as a model of brain-gut axis dysfunction.Psychopharmacology · 2011Review
- Sex differences in the response to influenza virus infection: modulation by stress.Hormones and behavior · 2011Article
- Effects of stress on the immune response to Theiler's virus--implications for virus-induced autoimmunity.Neuroimmunomodulation · 2010Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have established a link between adverse early life events and subsequent disease vulnerability. The present study assessed the long-term effects of neonatal maternal separation on the response to Theiler's murine encephalomyelitis virus infection, a model of multiple sclerosis. Balb/cJ mouse pups were separated from their dam for 180-min/day (180-min MS), 15-min/day (15-min MS), or left undisturbed from postnatal days 2-14. During adolescence, mice were infected with Theiler's virus and sacrificed at days 14, 21, or 35 post-infection. Prolonged 180-min MS increased viral load and delayed viral clearance in the spinal cords of males and females, whereas brief 15-min MS increased the rate of viral clearance in females. The 15-min and 180-min MS mice exhibited blunted corticosterone responses during infection, suggesting that reduced HPA sensitivity may have altered the immune response to infection. These findings demonstrate that early life events alter vulnerability to CNS infection later in life. Therefore, this model could be used to study gene-environment interactions that contribute to individual differences in susceptibility to infectious and autoimmune diseases of the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.