ArticleBasic research in cardiology2010
Low intrinsic aerobic exercise capacity and systemic insulin resistance are not associated with changes in myocardial substrate oxidation or insulin sensitivity.
Article in Basic research in cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression.Scientific reports · 2023Article
- Intrinsic Exercise Capacity Affects Glycine and Angiotensin-Converting Enzyme 2 (ACE2) Levels in Sedentary and Exercise Trained Rats.Metabolites · 2022Article
- The Effect of Age and Intrinsic Aerobic Exercise Capacity on the Expression of Inflammation and Remodeling Markers in Rat Achilles Tendons.International journal of molecular sciences · 2021Article
- Genetically determined exercise capacity affects systemic glucose response to insulin in rats.Physiological genomics · 2021Article
- Article
- Physiological and Biochemical Effects of Intrinsically High and Low Exercise Capacities Through Multiomics Approaches.Frontiers in physiology · 2019Article
- Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair.Neuroscience · 2013Article
- Rats selectively bred for differences in aerobic capacity have similar hypertensive responses to chronic intermittent hypoxia.American journal of physiology. Heart and circulatory physiology · 2013Article
- Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling.Antioxidants & redox signaling · 2013Review
- Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity.Physiological genomics · 2013Article
- A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart.Basic research in cardiology · 2011Article
- Exercise-induced modulation of cardiac lipid content in healthy lean young men.Basic research in cardiology · 2011Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
In patients, inactivity, obesity and insulin resistance are associated with increased incidence of heart failure. Rats selectively bred for low (LCR) intrinsic aerobic exercise capacity show signs of the metabolic syndrome including insulin resistance, compared to their counterparts bred for high intrinsic aerobic capacity (HCR). We reasoned that systemic insulin resistance in LCR should translate to impaired substrate oxidation and reduced insulin sensitivity in the heart. Isolated hearts were perfused in the working mode to analyze cardiac function, substrate oxidation patterns, insulin response, and oxygen consumption. After 22 generations of selective breeding, LCR displayed reduction of exercise capacity (LCR vs. HCR: distance 280 +/- 12 vs. 1,968 +/- 63 m, time 19.5 +/- 0.6 vs. 71.7 +/- 1.4 min, speed 19.2 +/- 0.3 vs. 45.3 +/- 0.7 m/min; all p < 0.05). At 21 weeks, body weight (+34%), tibia length (+6%), heart weight (+31%), and heart weight to tibia length ratio (+24%; all p < 0.05) were increased. LCR display higher random glucose, higher fasting glucose, and higher insulin levels in serum than HCR indicating the presence of insulin resistance in LCR. Here, in contrast, isolated hearts showed no differences in glucose (0.22 +/- 0.02 micromol/min/g dry) or fatty acid oxidation (0.79 +/- 0.10 micromol/min/g dry), oxygen consumption (28.3 +/- 4.1 nmol O(2)/min/g dry) or cardiac power (18.6 +/- 1.6 mW/g dry). Furthermore, sensitivity to insulin (Deltaglucose oxidation: +0.57 +/- 0.095 mumol/min/g dry) was not different between the two populations. Low intrinsic exercise capacity and systemic insulin resistance in rats are not associated with changes in cardiac substrate oxidation, insulin sensitivity, oxygen consumption, or cardiac function. The lack of cardiac insulin resistance in the face of systemic insulin resistance supports a concept of different pathomechanisms for these two conditions.
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