ArticlePediatric radiology2010
Transient elastography in patients with cystic fibrosis.
Article in Pediatric radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04380493 (Special Considerations for the Use of the Transient Elastography Paediatric Probe, Compared to the Standard M Probe, Indirect Serological Markers and Histology), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Special Considerations for the Use of the Transient Elastography Paediatric Probe, Compared to the Standard M Probe, Indirect Serological Markers and Histology
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Interventions for preventing and managing advanced liver disease in cystic fibrosis.The Cochrane database of systematic reviews · 2020Pooled it
- Interventions for preventing and managing advanced liver disease in cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Trial
- Cystic fibrosis hepatobiliary involvement: an update on imaging in diagnosis and monitoring.Pediatric radiology · 2024Review
- Liver magnetic resonance elastography and fat fraction in pediatric patients with cystic fibrosis versus healthy children.Pediatric radiology · 2024Article
- Heterogeneous liver on research ultrasound identifies children with cystic fibrosis at high risk of advanced liver disease.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023Observational
- Cystic fibrosis and noninvasive liver fibrosis assessment methods in children.Pediatric research · 2022Article
- Assessment of Liver Fibrosis with the Use of Elastography in Paediatric Patients with Diagnosed Cystic Fibrosis.Disease markers · 2022Article
- Non-invasive tools for detection of liver disease in children and adolescents with cystic fibrosis.Translational pediatrics · 2021Article
- Menstrual Pain and Elasticity of Uterine Cervix.Journal of clinical medicine · 2021Article
- Role of transient elastography and APRI in the assessment of pediatric cystic fibrosis liver disease.Canadian liver journal · 2021Article
- Repeatability of transient elastography in children.Pediatric research · 2020Article
- [Abdominal imaging in cystic fibrosis].Der Radiologe · 2020Review
- Heterogeneous Liver on Research Ultrasound Identifies Children with Cystic Fibrosis at High Risk of Advanced Liver Disease: Interim Results of a Prospective Observational Case-Controlled Study.The Journal of pediatrics · 2020Observational
- Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods.Journal of pediatric gastroenterology and nutrition · 2019Article
- Transient Elastography in the Evaluation of Cystic Fibrosis-Associated Liver Disease: Systematic Review and Meta-analysis.Journal of the Canadian Association of Gastroenterology · 2019Article
- Advances in diagnosis of chronic liver diseases in pediatric patients.World journal of pediatrics : WJP · 2018Review
- Feasibility of 2-D ultrasound shear wave elastography of fetal lungs in case of threatened preterm labour: a study protocol.BMJ open · 2017Article
- Adult-onset cystic fibrosis liver disease: Diagnosis and characterization of an underappreciated entity.Hepatology (Baltimore, Md.) · 2017Article
- Ultrasonography: Applications in Pediatric Abdomen.Indian journal of pediatrics · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatic involvement is frequent in patients with cystic fibrosis (CF), with focal biliary cirrhosis being the pathognomonic hepatic manifestation. In around one-quarter of CF patients, it results in CF-associated liver disease (CFLD). This occurs as a relatively early complication with the majority of patients presenting in childhood or their early teens. However, a normal US does not preclude significant liver fibrosis and liver biopsy is an invasive procedure that is hampered by potential sampling errors. Transient elastography (TE) (Fibroscan) is a non-invasive, user-friendly and quick technique that provides an objective and reproducible measure of liver stiffness. This is accomplished with a device using an US probe mounted in the axis of a vibrator. Vibrations are transmitted by the transducer, inducing an electronic shear wave that propagates through the underlying tissue.
objectivesWe aimed to prospectively compare TE and transabdominal US scanning in children and adults attending a CF clinic. MATERIALS AND
methodsA total of 134 consecutive patients with documented CF were prospectively studied. In each case, transient elastography measurement was performed immediately after the routine annual US evaluation of the liver. Sonographic appearance of the liver was classified from 1 to 5. Ten validated TE measurements were performed in each patient with the result expressed in kilopascals (kPa). The median value was considered representative of the elastic modulus of the liver.
resultsMeasurements were performed in 59 CF adults, 75 CF children and 31 control children. There was no relationship between age and liver stiffness in either the control group or CF patients. Elasticity values of controls, CF pancreatic sufficient (PS) patients and pancreatic insufficient (PI) CF patients with a US score <3 were comparable and significantly lower than in CF patients with a US score > or = 3 (all PI) (P < 0.002). Median elasticity in CF patients was significantly higher in males (4.7 kPa) than in females (3.9 kPa) (P = 0.0013).
conclusionConsidering the limitations of US and the low risk-benefit rate of liver biopsy in most CF patients, this preliminary study suggests that TE is an attractive non-invasive way to assess and follow-up liver disease in these patients.
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