ArticleEMBO reports2010
A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth.
Article in EMBO reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- The insulin-like growth factor 2 gene in mammals: Organizational complexity within a conserved locus.PloS one · 2019Article
- The insulin-like growth factor 2 gene and locus in nonmammalian vertebrates: Organizational simplicity with duplication but limited divergence in fish.The Journal of biological chemistry · 2018Article
- Similarity and variation in the insulin-like growth factor 2 - H19 locus in primates.Physiological genomics · 2018Article
- The complex genetics of human insulin-like growth factor 2 are not reflected in public databases.The Journal of biological chemistry · 2018Article
- TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.PLoS pathogens · 2017Article
- Phylointeractomics reconstructs functional evolution of protein binding.Nature communications · 2017Article
- Proteomics to study DNA-bound and chromatin-associated gene regulatory complexes.Human molecular genetics · 2016Article
- Characterizing a distal muscle enhancer in the mouse Igf2 locus.Physiological genomics · 2016Article
- Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.Nature structural & molecular biology · 2015Article
- Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Polymorphisms in the feline TNFA and CD209 genes are associated with the outcome of feline coronavirus infection.Veterinary research · 2014Article
- Genomics meets proteomics: identifying the culprits in disease.Human genetics · 2014Review
- Article
- Transcription factor ZBED6 affects gene expression, proliferation, and cell death in pancreatic beta cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Reliability of the nanopheres-DNA immunization technology to produce polyclonal antibodies directed against human neogenic proteins.Molecular genetics and genomics : MGG · 2013Article
- Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment.American journal of human genetics · 2013Article
- HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.The EMBO journal · 2013Article
- Proteomics in epigenetics: new perspectives for cancer research.Briefings in functional genomics · 2013Review
- Mass spectrometry-based proteomics for the analysis of chromatin structure and dynamics.International journal of molecular sciences · 2013Article
- Defining Akt actions in muscle differentiation.American journal of physiology. Cell physiology · 2012Article
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5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-nucleotide polymorphisms (SNPs) in the regulatory regions of the genome can have a profound impact on phenotype. The G3072A polymorphism in intron 3 of insulin-like growth factor 2 (IGF2) is implicated in higher muscle content and reduced fat in European pigs and is bound by a putative repressor. Here, we identify this repressor--which we call muscle growth regulator (MGR)--by using a DNA protein interaction screen based on quantitative mass spectrometry. MGR has a bipartite nuclear localization signal, two BED-type zinc fingers and is highly conserved between placental mammals. Surprisingly, the gene is located in an intron and belongs to the hobo-Ac-Tam3 transposase superfamily, suggesting regulatory use of a formerly parasitic element. In transactivation assays, MGR differentially represses the expression of the two SNP variants. Knockdown of MGR in C2C12 myoblast cells upregulates Igf2 expression and mild overexpression retards growth. Thus, MGR is the repressor responsible for enhanced muscle growth in the IGF2 G3072A polymorphism in commercially bred pigs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.