ArticleNature protocols2010
Bilateral multielectrode neurophysiological recordings coupled to local pharmacology in awake songbirds.
Article in Nature protocols, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing.British journal of pharmacology · 2015Article
- Mechanistic basis and functional roles of long-term plasticity in auditory neurons induced by a brain-generated estrogen.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Changing neuroestrogens within the auditory forebrain rapidly transform stimulus selectivity in a downstream sensorimotor nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Brain-generated estradiol drives long-term optimization of auditory coding to enhance the discrimination of communication signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we describe a protocol for bilateral multielectrode neurophysiological recordings during intracerebral pharmacological manipulations in awake songbirds. This protocol encompasses fitting adult animals with head-posts and recording chambers, and acclimating them to periods of restraint. The adaptation period is followed by bilateral penetrations of multiple electrodes to obtain acute, sensory-driven neurophysiological responses before versus during the application of pharmacological agents of interest. These local manipulations are achieved by simultaneous and restricted drug infusions carried out independently for each hemisphere. We have used this protocol to elucidate how neurotransmitter and neuroendocrine systems shape the auditory and perceptual processing of natural, learned communication signals. However, this protocol can be used to explore the neurochemical basis of sensory processing in other small vertebrates. Representative results and troubleshooting of key steps of this protocol are presented. Following the animal's recovery from head-post and recording chamber implantation surgery, the length of the procedure is 2 d.
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