Evidence map›Paper›PMID 20134026›Full record

ReviewPhysiology (Bethesda, Md.)2010

Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes.

Thomas E DeCoursey

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Voltage-gated proton channel Hv1/VSOP regulates reciprocal interactions between F-actin and endosomes in microglia.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Transcendent Aspects of Proton Channels.Annual review of physiology · 2024
    Review
  4. Ion fluxes Involved in the Adaptation of the Estuarine DiatomInternational journal of molecular sciences · 2023
    Article
  5. Article
  6. Expression of HProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Hydrophobic gasket mutation produces gating pore currents in closed human voltage-gated proton channels.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  15. Article
  16. HistidineThe Journal of general physiology · 2018
    Article
  17. Voltage and pH sensing by the voltage-gated proton channel, HJournal of the Royal Society, Interface · 2018
    Review
  18. On the role of water density fluctuations in the inhibition of a proton channel.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Thomas E DeCourseyDepartment of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, USA. tdecours@rush.edu

Funding

VOLTAGE-GATED PROTON CHANNELS IN HUMAN NEUTROPHILSR01HL061437 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI DECOURSEY, THOMAS E · 2000 to 2008
$2.6M
Structure-Function Releationships of Voltage-Gated Proton ChannelsR01GM087507 · NIGMS · RUSH UNIVERSITY MEDICAL CENTER · PI DECOURSEY, THOMAS E · 2010 to 2013
$1.2M
NHLBI NIH HHS HL-61437NHLBI NIH HHS R01 HL061437NIGMS NIH HHS R01 GM087507
6 · The paper itself

Abstract

The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1-S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.

Indexed as

Ion Channel GatingRespiratory BurstSignal TransductionAmino Acid SequenceAnimalsCell Membrane PermeabilityHumansHydrogen-Ion ConcentrationIon ChannelsMembrane PotentialsModels, BiologicalMolecular Sequence DataNADPH OxidasesPhagocytesProtein ConformationProtein MultimerizationIon ChannelsNADPH OxidasesProtonsReactive Oxygen Species

Identifiers

PMID20134026
PMCPMC3023998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.