ArticleStroke2010
Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke.
Article in Stroke, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- DNA methylation and stroke prognosis: an epigenome-wide association study.Clinical epigenetics · 2024Pooled it
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis.Stroke · 2011Pooled it
- Effects of sartans and low-dose statins on cerebral white matter hyperintensities and cognitive function in older patients with hypertension: a randomized, double-blind and placebo-controlled clinical trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Trial
- Region-specific vulnerability to vascular risk factors and modifiable protective influences on white matter hyperintensities.Communications medicine · 2026Article
- Advancing clinical trial readiness in white matter disease and related dementias: key steps for future research progress.GeroScience · 2026Article
- Plasma lipidomic profiling reveals the potential protective role of lipids in cerebral small vessel disease.Lipids in health and disease · 2026Article
- Relationship Between Carotid Artery Anatomy and Geometry and White Matter Hyperintensities and Accompanying Comorbid Factors.Tomography (Ann Arbor, Mich.) · 2026Article
- Distinct spatiotemporal patterns of white matter hyperintensity progression.Nature communications · 2025Article
- Predicting White Matter Hyperintensity: Leveraging Portable MRI for Accessible Brain Health Screening.AJNR. American journal of neuroradiology · 2025Article
- Differences in Cerebral Small Vessel Disease Magnetic Resonance Imaging Depending on Cardiovascular Risk Factors: A Retrospective Cross-Sectional Study.Brain sciences · 2025Article
- Plasma Metabolites Link Non-Communicable Diseases to Increased White Matter Hyperintensities.CNS neuroscience & therapeutics · 2025Article
- Risk factor differences in five-year progression of Intracranial artery stenosis and cerebral small vessel disease in general population.BMC neurology · 2024Article
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- Quantitative Analysis of Multimodal MRI Markers and Clinical Risk Factors for Cerebral Small Vessel Disease Based on Deep Learning.International journal of general medicine · 2024Article
- Low serum HDL-cholesterol is associated with increased risk of the subcortical small vessel type of dementia.Cerebral circulation - cognition and behavior · 2024Article
- A nomogram for predicting cerebral white matter lesions in elderly men.Frontiers in neurology · 2024Article
- Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.Molecular neurodegeneration · 2023Review
- Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol.Journal of Alzheimer's disease : JAD · 2023Article
- Association of Plasma Lipids with White Matter Hyperintensities in Patients with Acute Ischemic Stroke.International journal of general medicine · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeWhite matter hyperintensity (WMH), or leukoaraiosis, is a radiologic finding generally assumed to reflect diseased small cerebral vasculature. WMH has significant functional impact through its relation to cognitive decline and risk of ischemic and hemorrhagic stroke. Accumulating evidence suggests that some manifestations of small-vessel disease such as intracerebral hemorrhage are associated with low levels of cholesterol. We sought to determine the relation between hyperlipidemia and WMH severity in patients with acute ischemic stroke (AIS).
methodsWe analyzed 2 independent, hospital-based AIS cohorts. Demographic and clinical data were collected prospectively. WMH was measured using semiautomated volumetric image analysis and a semiquantitative visual grading scale. Univariate and multivariable regression analyses were used to assess the relation between WMH severity and study variables.
resultsA total of 631 and 504 subjects in the first and second cohorts, respectively, were included. In univariate analyses, advancing age and hypertension were associated with severity of WMH (P<0.001) in both cohorts. In the multivariable analysis, after controlling for age, sex, and significant risk factors in the univariate and age-adjusted analyses, patients with a history of hyperlipidemia had less severe WMH in both cohorts (P<0.01).
conclusionsResults from 2 independent cohorts demonstrate that AIS patients with a history of hyperlipidemia have less severe WMH at the time of stroke. These data support the hypothesis that hyperlipidemia may play a relatively protective role in cerebral small-vessel disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.