ArticleProceedings of the National Academy of Sciences of the United States of America2010
PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 314 papers.
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Who cites it
314 citing papers in PubMed, 761 citations in OpenAlex.
- Beyond membrane transport: Transporters as dynamic signal integrators for plant signaling and adaptation.Plant communications · 2026Review
- Guard cell signal transduction mechanisms controlling stomatal movements by light, abscisic acid, CO2, VPD and heat.Plant physiology · 2026Review
- Abscisic Acid-Mediated Drought Tolerance inCurrent issues in molecular biology · 2026Review
- Gene network analysis predicts the primary regulators of ABA-dependent transcriptional activation and repression in Populus roots.PLoS genetics · 2026Article
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Genome-wide analysis of the NAC gene family in Qu-1 doubled haploid cell line from Populus simonii × P. nigra and expression patterns under abscisic acid (ABA) treatment.BMC plant biology · 2026Article
- Spatial distribution of isoprenoid enzymes and MpABCG1 transporter influences sesquiterpene accumulation in Marchantia polymorpha oil bodies.Communications biology · 2026Article
- Article
- Pan-transcriptome analysis of pine wilt disease-resistant and susceptibleFrontiers in genetics · 2026Article
- Genomic and Transcriptomic Insights into Stage-Specific Drought Resilience in Diverse Myanmar Rice Germplasm.Rice (New York, N.Y.) · 2025Article
- BAM1/2-mediated phosphorylation of ABCG16 reduces its stability and ABA export activity to suppress root growth in Arabidopsis.Plant communications · 2025Article
- Salt Tolerance in Soybean (Plants (Basel, Switzerland) · 2025Review
- The plastid cysteine synthase complex regulates ABA biosynthesis and stomatal closure in Arabidopsis.Nature communications · 2025Article
- De novo transcriptome analysis and functional annotation of Silybum Marianum L. under drought stress with a focus on Silymarin synthesis and MAPK signaling pathways.BMC plant biology · 2025Article
- Genome-wide analysis of the AarPDR gene family in Artemisia argyi and its potential role in regulating terpenoids transport.BMC plant biology · 2025Article
- Myosin XI coordinates ABA-induced stomatal closure via microtubule stability and ROS synthesis in drought-stressed Arabidopsis.Plant cell reports · 2025Article
- Deciphering ABA/PYL gene family in flax: evolutionary analysis, and abiotic stress response.Plant cell reports · 2025Article
- The triggering mechanism for predominant hormonal signal production in fleshy fruit ripening.Molecular horticulture · 2025Review
- Transcriptional gene network involved in drought stress response: application for crop breeding in the context of climate change.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period.BMC plant biology · 2025Article
254 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abscisic acid (ABA) is a ubiquitous phytohormone involved in many developmental processes and stress responses of plants. ABA moves within the plant, and intracellular receptors for ABA have been recently identified; however, no ABA transporter has been described to date. Here, we report the identification of the ATP-binding cassette (ABC) transporter Arabidopsis thaliana Pleiotropic drug resistance transporter PDR12 (AtPDR12)/ABCG40 as a plasma membrane ABA uptake transporter. Uptake of ABA into yeast and BY2 cells expressing AtABCG40 was increased, whereas ABA uptake into protoplasts of atabcg40 plants was decreased compared with control cells. In response to exogenous ABA, the up-regulation of ABA responsive genes was strongly delayed in atabcg40 plants, indicating that ABCG40 is necessary for timely responses to ABA. Stomata of loss-of-function atabcg40 mutants closed more slowly in response to ABA, resulting in reduced drought tolerance. Our results integrate ABA-dependent signaling and transport processes and open another avenue for the engineering of drought-tolerant plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.