ArticleProceedings of the National Academy of Sciences of the United States of America2010
Molecular keys of the tropism of integration of the cholera toxin phage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 61 citations in OpenAlex.
- A decade of antimicrobial resistance inMicrobiology spectrum · 2026Article
- Cholera Dynamics and the Emergence of Pandemic Vibrio cholerae.Advances in experimental medicine and biology · 2023Article
- The Xer activation factor of TLCΦ expands the possibilities for Xer recombination.Nucleic acids research · 2022Article
- VicPred: AFrontiers in microbiology · 2021Article
- Molecular insights into the genome dynamics and interactions between core and acquired genomes ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Beyond Cholera: Characterization ofViruses · 2020Article
- Vibrio Pathogenicity Island-1: The Master Determinant of Cholera Pathogenesis.Frontiers in cellular and infection microbiology · 2020Review
- Insights into TLCΦ lysogeny: A twist in the mechanism of IMEX integration.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The TLCΦ satellite phage harbors a Xer recombination activation factor.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Filamentous phages: masters of a microbial sharing economy.EMBO reports · 2019Review
- Cholera: an overview with reference to the Yemen epidemic.Frontiers of medicine · 2019Review
- Increased Flexibility between Stems of Intramolecular Three-Way Junctions by the Insertion of Bulges.Biophysical journal · 2018Article
- Design and Construction ofFrontiers in microbiology · 2018Article
- Electrostatic interactions between the CTX phage minor coat protein and the bacterial host receptor TolA drive the pathogenic conversion ofThe Journal of biological chemistry · 2017Article
- Investigation of the Melting Behavior of DNA Three-Way Junctions in the Closed and Open States.Biophysical journal · 2017Article
- Fast growth conditions uncouple the final stages of chromosome segregation and cell division in Escherichia coli.PLoS genetics · 2017Article
- How Xer-exploiting mobile elements overcome cellular control.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Effect of LexA on Chromosomal Integration of CTXϕ in Vibrio cholerae.Journal of bacteriology · 2016Article
- CTXφ Replication Depends on the Histone-Like HU Protein and the UvrD Helicase.PLoS genetics · 2015Article
- A novel, broad-range, CTXΦ-derived stable integrative expression vector for functional studies.Journal of bacteriology · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Cholera toxin is encoded in the genome of CTXvarphi, a lysogenic filamentous phage of Vibrio cholerae. CTXvarphi variants contribute to the genetic diversity of cholera epidemic strains. It has been shown that the El Tor variant of CTXvarphi hijacks XerC and XerD, two host-encoded tyrosine recombinases that normally function to resolve chromosome dimers, to integrate at dif1, the dimer resolution site of the larger of the two V. cholerae chromosomes. However, the exact mechanism of integration of CTXvarphi and the rules governing its integration remained puzzling, with phage variants integrated at either or both dimer resolution sites of the two V. cholerae chromosomes. We designed a genetic system to determine experimentally the tropism of integration of CTXvarphi and thus define rules of compatibility between phage variants and dimer resolution sites. We then showed in vitro how these rules are explained by the direct integration of the single-stranded phage genome into the double-stranded bacterial genome. Finally, we showed how the evolution of phage attachment and chromosome dimer resolution sites contributes to the generation of genetic diversity among cholera epidemic strains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.