ArticleProceedings of the National Academy of Sciences of the United States of America2010
Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Evaluating the prognostic significance of HIST1H4C in breast cancer: implications for neoadjuvant therapy.Scientific reports · 2026Article
- A distinct phase of cyclin B (Cdc13) nuclear export at mitotic entry inOpen biology · 2025Article
- CDK activity at the centrosome regulates the cell cycle.Cell reports · 2024Article
- Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila.Nature communications · 2022Article
- Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms.iScience · 2021Article
- A guiding torch at the poles: the multiple roles of spindle microtubule-organizing centers during cell division.Cell cycle (Georgetown, Tex.) · 2020Review
- The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis.Current biology : CB · 2020Article
- DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.Nature communications · 2017Article
- Quantitative Systems Biology to decipher design principles of a dynamic cell cycle network: the "Maximum Allowable mammalian Trade-Off-Weight" (MAmTOW).NPJ systems biology and applications · 2017Review
- The Centrosome, a Multitalented Renaissance Organelle.Cold Spring Harbor perspectives in biology · 2016Review
- Opposing post-translational modifications regulate Cep76 function to suppress centriole amplification.Oncogene · 2016Article
- BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.Cell cycle (Georgetown, Tex.) · 2016Article
- Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes.Cell research · 2013Article
- Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis.Cancer science · 2013Article
- In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation?Nature reviews. Cancer · 2013Review
- Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase.The Journal of biological chemistry · 2012Article
- Steroidogenic Factor 1 (NR5A1) resides in centrosomes and maintains genomic stability by controlling centrosome homeostasis.Cell death and differentiation · 2011Article
- Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.The Journal of cell biology · 2011Article
- Centrosomal localization of cyclins E and A: structural similarities and functional differences.Cell cycle (Georgetown, Tex.) · 2011Article
- The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication.Journal of cell science · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Centrosomes have recently emerged as key regulators of the cell cycle. The G1/S transition requires a functional centrosome, and centrosomal localization of numerous proteins, including cyclin/Cdk complexes, is important for the G2/M transition. Here we identify a modular centrosomal localization signal (CLS) localizing cyclin A to centrosomes independently of Cdk binding. The cyclin A CLS is located in a distinct part of the molecule compared with the cyclin E CLS and includes the MRAIL hydrophobic patch involved in substrate recognition. The cyclin A CLS interacts with p27(KIP1), and expression of p27(KIP1) removes cyclin A but not cyclin E from centrosomes. Expression of the cyclin A CLS displaces both endogenous cyclin A and E from centrosomes and inhibits DNA replication, supporting an emerging concept that DNA replication is linked to centrosomal events. Structural analysis indicates that differences in surface charge and length of the C-terminal helix explain why the MRAIL region in cyclin E is not a functional CLS. These results indicate that the cyclin A CLS may contribute to targeting and recognition of centrosomal Cdk substrates and is required for specific effects of p27(KIP1) on cyclin A-Cdk2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.