ArticleProceedings of the National Academy of Sciences of the United States of America2010
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Perinatal brain developmental transition revealed by transcriptomic and proteomic analyses of Bama miniature pigs.Nature communications · 2026Article
- Cohesin protein Smc3 influences kinocilial structure and function.Biology open · 2025Article
- NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody.Protein & cell · 2024Article
- NUDC is critical for rod photoreceptor function, maintenance, and survival.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Small Sized Yet Powerful: Nuclear Distribution C Proteins in Plants.Plants (Basel, Switzerland) · 2023Review
- NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.Cell research · 2021Article
- NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration.Frontiers in cell and developmental biology · 2021Article
- NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.Cell death & disease · 2020Article
- Review
- Overexpression of theFrontiers in plant science · 2020Article
- NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.Cell death & disease · 2019Article
- Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome.Frontiers in cellular neuroscience · 2019Article
- NudCL2 is an Hsp90 cochaperone to regulate sister chromatid cohesion by stabilizing cohesin subunits.Cellular and molecular life sciences : CMLS · 2019Article
- NudCD1 affects renal cell carcinoma through regulating LIS1/Dynein signaling pathway.American journal of translational research · 2018Article
- NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.Cell research · 2016Article
- PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.Nature cell biology · 2015Article
- EML4 promotes the loading of NUDC to the spindle for mitotic progression.Cell cycle (Georgetown, Tex.) · 2015Article
- Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes.Cell research · 2013Article
- The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells.PloS one · 2013Article
- Approaches for defining the Hsp90-dependent proteome.Biochimica et biophysica acta · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC, NudCL2 (NudC-like protein 2), as a regulator of LIS1. NudCL2 is localized to the centrosome in interphase, and spindle poles and kinetochores during mitosis, a pattern similar to the localization of LIS1 and cytoplasmic dynein. Depletion of NudCL2 destabilized LIS1 and led to phenotypes resembling those of either dynein or LIS1 deficiency. NudCL2 complexed with and enhanced the interaction between LIS1 and Hsp90. Either disruption of the LIS1-Hsp90 interaction with the C terminus of NudCL2 or inhibition of Hsp90 chaperone function by geldanamycin decreased LIS1 stability. Thus, our results suggest that NudCL2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. This represents a hitherto undescribed mechanism of the LIS1/dynein regulation in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.