ArticleProceedings of the National Academy of Sciences of the United States of America2010
Capillarity theory for the fly-casting mechanism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
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- The transition state for coupled folding and binding of a disordered DNA binding domain resembles the unbound state.Nucleic acids research · 2024Article
- Correlating Disordered Activation Domain Ensembles with Gene Expression Levels.bioRxiv : the preprint server for biology · 2024Article
- BAP1 is a novel regulator of HIF-1α.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Coupled binding and folding of disordered SPIN N-terminal region in myeloperoxidase inhibition.Frontiers in molecular biosciences · 2023Article
- Interplay of Affinity and Surface Tethering in Protein Recognition.The journal of physical chemistry letters · 2022Article
- Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer.Molecular cancer research : MCR · 2021Article
- Surveying biomolecular frustration at atomic resolution.Nature communications · 2020Article
- Intrinsically Disordered Proteins: Insights from Poincaré, Waddington, and Lamarck.Biomolecules · 2020Article
- A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.Science signaling · 2020Article
- Features of molecular recognition of intrinsically disordered proteins via coupled folding and binding.Protein science : a publication of the Protein Society · 2019Review
- Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level.Biomolecules · 2019Article
- Tunable order-disorder continuum in protein-DNA interactions.Nucleic acids research · 2018Article
- PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer.Journal of molecular biology · 2018Article
- Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.Nature reviews. Cancer · 2018Review
- Co-operative intra-protein structural response due to protein-protein complexation revealed through thermodynamic quantification: study of MDM2-p53 binding.Journal of computer-aided molecular design · 2017Article
- Challenges in structural approaches to cell modeling.Journal of molecular biology · 2016Review
- Membrane-Induced Folding of the Plant Stress Dehydrin Lti30.Plant physiology · 2016Article
- The new (dis)order in RNA regulation.Cell communication and signaling : CCS · 2016Review
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3 authors.
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Abstract
Biomolecular folding and function are often coupled. During molecular recognition events, one of the binding partners may transiently or partially unfold, allowing more rapid access to a binding site. We describe a simple model for this fly-casting mechanism based on the capillarity approximation and polymer chain statistics. The model shows that fly casting is most effective when the protein unfolding barrier is small and the part of the chain which extends toward the target is relatively rigid. These features are often seen in known examples of fly casting in protein-DNA binding. Simulations of protein-DNA binding based on well-funneled native-topology models with electrostatic forces confirm the trends of the analytical theory.
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