ArticleProceedings of the National Academy of Sciences of the United States of America2010
Mechanical amplification by hair cells in the semicircular canals.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Adaptation of vestibular signals for self-motion perception.The Journal of physiology · 2011Trial
- Personalized medicine to treat refractory benign paroxysmal positional vertigo, through computational fluid dynamics analysis from magnetic resonance image reconstructions.Frontiers in neurology · 2025Article
- In Full Force. Mechanotransduction and Morphogenesis during Homeostasis and Tissue Regeneration.Journal of cardiovascular development and disease · 2020Review
- Efferent synaptic transmission at the vestibular type II hair cell synapse.Journal of neurophysiology · 2020Article
- Semicircular canal biomechanics in health and disease.Journal of neurophysiology · 2019Review
- Sound abnormally stimulates the vestibular system in canal dehiscence syndrome by generating pathological fluid-mechanical waves.Scientific reports · 2018Article
- ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.Journal of neurophysiology · 2018Article
- Influence of Magnitude and Duration of Altered Gravity and Readaptation to 1 g on the Structure and Function of the Utricle in Toadfish,Frontiers in physiology · 2018Article
- Wave Mechanics of the Vestibular Semicircular Canals.Biophysical journal · 2017Article
- New data about semicircular canal morphology and locomotion in modern hominoids.Journal of anatomy · 2017Article
- Adaptive Changes in the Vestibular System of Land Snail to a 30-Day Spaceflight and Readaptation on Return to Earth.Frontiers in cellular neuroscience · 2017Article
- Reviewing the Role of the Efferent Vestibular System in Motor and Vestibular Circuits.Frontiers in physiology · 2017Review
- BODIPY-Conjugated Xyloside Primes Fluorescent Glycosaminoglycans in the Inner Ear of Opsanus tau.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Semicircular Canals Circumvent Brownian Motion Overload of Mechanoreceptor Hair Cells.PloS one · 2016Article
- Hair cell-type dependent expression of basolateral ion channels shapes response dynamics in the frog utricle.Frontiers in cellular neuroscience · 2015Article
- Evidence that protons act as neurotransmitters at vestibular hair cell-calyx afferent synapses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Electrokinetic properties of the mammalian tectorial membrane.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mechanical overstimulation of hair bundles: suppression and recovery of active motility.PloS one · 2013Article
- The anatomical and physiological framework for vestibular prostheses.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
- A distributed, dynamic, parallel computational model: the role of noise in velocity storage.Journal of neurophysiology · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sensory hair cells are the essential mechanotransducers of the inner ear, responsible not only for the transduction of sound and motion stimuli but also, remarkably, for nanomechanical amplification of sensory stimuli. Here we show that semicircular canal hair cells generate a mechanical nonlinearity in vivo that increases sensitivity to angular motion by amplification at low stimulus strengths. Sensitivity at high stimulus strengths is linear and shows no evidence of amplification. Results suggest that the mechanical work done by hair cells contributes approximately 97 zJ/cell of amplification per stimulus cycle, improving sensitivity to angular velocity stimuli below approximately 5 degrees /s (0.3-Hz sinusoidal motion). We further show that mechanical amplification can be inhibited by the brain via activation of efferent synaptic contacts on hair cells. The experimental model was the oyster toadfish, Opsanus tau. Physiological manifestation of mechanical amplification and efferent control in a teleost vestibular organ suggests the active motor process in sensory hair cells is ancestral. The biophysical basis of the motor(s) remains hypothetical, but a key discriminating question may involve how changes in somatic electrical impedance evoked by efferent synaptic action alter function of the motor(s).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.