ArticleProceedings of the National Academy of Sciences of the United States of America2010
Dynamic regulation of functionally distinct virus-specific T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- AIM™ platform: A new immunotherapy approach for viral diseases.Frontiers in medicine · 2022Article
- Rapid Expansion of Highly Functional Antigen-Specific T Cells from Patients with Melanoma by Nanoscale Artificial Antigen-Presenting Cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Article
- CD47 Enhances In Vivo Functionality of Artificial Antigen-Presenting Cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Linking form to function: Biophysical aspects of artificial antigen presenting cell design.Biochimica et biophysica acta · 2015Review
- Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells.Biomaterials · 2014Article
- Sprouty-2 regulates HIV-specific T cell polyfunctionality.The Journal of clinical investigation · 2014Article
- Nanoengineering approaches to the design of artificial antigen-presenting cells.Nanomedicine (London, England) · 2013Review
- Biomimetic delivery with micro- and nanoparticles.Advanced materials (Deerfield Beach, Fla.) · 2012Review
- Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses.Journal of virology · 2012Article
- A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis.The Journal of clinical investigation · 2011Article
- Article
- Article
- Human leukocyte antigens A*3001 and A*3002 show distinct peptide-binding patterns of the Mycobacterium tuberculosis protein TB10.4: consequences for immune recognition.Clinical and vaccine immunology : CVI · 2011Article
- T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.Blood · 2010Article
- Novel cellular microarray assay for profiling T-cell peptide antigen specificities.Journal of proteome research · 2010Article
- Article
- Long-lasting multifunctional CD8OncoimmunologyArticle
- Artificial antigen-presenting cells for use in adoptive immunotherapy.Cancer journal (Sudbury, Mass.)Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The functional capacities of CD8(+) T cells important for virus clearance are influenced by interactions with antigen presenting cells (APCs) and CD4(+) T cells during initial selection, subsequent expansion, and development of memory. Recently, investigators have shown that polyfunctional T cells correlate best with long-term protection, however, it is still unknown how to stimulate T cells to achieve these responses. To study this, we examined the phenotypes and functions of CD8(+) T cells specific for two different virus antigens stimulated ex vivo using either autologous monocyte-derived dendritic cells (moDCs) or HLA-A2-Ig-based artificial APCs (aAPCs). Although similar numbers of influenza virus and measles virus tetramer-positive cells were generated by stimulation with peptide-loaded moDCs and aAPCs, T cell function, assessed by expression of IL-2, IFN-gamma, TNF-alpha, MIP1beta, and CD107a, showed that aAPC-generated CD8(+) T cells were multifunctional, whereas moDC-generated cells were mostly monofunctional. aAPC-generated cells also produced more of each cytokine per cell than CD8(+) T cells generated with moDCs. These phenotypes were not fixed, as changing the culture conditions of expanding T cells from aAPCs to moDCs, and moDCs to aAPCs, reversed the phenotypes. We conclude that CD8(+) T cells are heterogeneous in their functionality and that this is dependent, in a dynamic way, on the stimulating APC. These studies will lead to understanding the factors that influence induction of optimal CD8(+) T cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.