ArticleProceedings of the National Academy of Sciences of the United States of America2010
Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 86 citations in OpenAlex.
- Macrophage-T Cell Physical Interaction Modulates IFN-γ Secretion.ACS applied materials & interfaces · 2025Article
- Viscocohesive hyaluronan gel enhances stability of intravital multiphoton imaging with subcellular resolution.Neurophotonics · 2025Article
- Classification of T lymphocyte motility behaviors using a machine learning approach.PLoS computational biology · 2023Article
- Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging.Immunological reviews · 2022Review
- Imaging viral infection in vivo to gain unique perspectives on cellular antiviral immunity.Immunological reviews · 2022Review
- Intravital fluorescence microscopy with negative contrast.PloS one · 2021Article
- Visualization and characterization of metallo-aggregates using multi-photon microscopy.RSC advances · 2020Article
- DNA probes that store mechanical information reveal transient piconewton forces applied by T cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Review
- Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes.ACS chemical biology · 2018Article
- A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4Scientific reports · 2018Article
- Adhesive Interactions Delineate the Topography of the Immune Synapse.Frontiers in cell and developmental biology · 2018Review
- Role of Mechanotransduction and Tension in T Cell Function.Frontiers in immunology · 2018Review
- Imaging Polarized Secretory Traffic at the Immune Synapse in Living T Lymphocytes.Frontiers in immunology · 2018Review
- Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine.JCI insight · 2016Article
- The Role of Lymphatic Niches in T Cell Differentiation.Molecules and cells · 2016Review
- Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Conserved and divergent aspects of human T-cell development and migration in humanized mice.Immunology and cell biology · 2015Article
- Stable interactions and sustained TCR signaling characterize thymocyte-thymocyte interactions that support negative selection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Human Immunodeficiencies Related to Defective APC/T Cell Interaction.Frontiers in immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro studies have revealed that T cell activation occurs during the formation of either dynamic or stable interactions with antigen-presenting cells (APC), and the respective cell junctions have been referred to as immunological kinapses and synapses. However, the relevance and molecular dynamics of kinapses and synapses remain to be established in vivo. Using two-photon imaging, we tracked the distribution of LAT-EGFP molecules during antigen recognition by activated CD4(+) T cells in lymph nodes. At steady state, LAT-EGFP molecules were preferentially found at the uropod of rapidly migrating T cells. In contrast to naïve T cells that fully stopped upon systemic antigen delivery, recently activated T cells decelerated and formed kinapses, characterized by continuous extension of membrane protrusions and by the absence of persistent LAT-EGFP clustering. On the other hand, activated CD4(+) T cells formed stable immunological synapses with antigen-loaded B cells and displayed sustained accumulation of LAT-EGFP fluorescence at the contact zone. Our results show that the state of T cell activation and the type of APC largely influence T cell-APC contact dynamics in lymph nodes. Furthermore, we provide a dynamic look at immunological kinapses and synapses in lymph nodes and suggest the existence of distinct patterns of LAT redistribution during antigen recognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.