ArticleProceedings of the National Academy of Sciences of the United States of America2010
Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits.Human psychopharmacology · 2023Pooled it
- Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review.Journal of psychiatry & neuroscience : JPNPooled it
- Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Trial
- Dopamine manipulations modulate paranoid social inferences in healthy people.Translational psychiatry · 2020Trial
- Levodopa administration modulates striatal processing of punishment-associated items in healthy participants.Psychopharmacology · 2015Trial
- Dopamine modulates risk-taking as a function of baseline sensation-seeking trait.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Peripheral Expression of Dopamine Genes as a Biomarker for Cocaine Addiction in Humans.European addiction research · 2026Article
- Alternative Reinforcers Enhance the Effects of Opioid Antagonists, but Not Agonists, on Oxycodone Choice Self-Administration in Nonhuman Primates.The Journal of pharmacology and experimental therapeutics · 2024Article
- Indirect evidence for altered dopaminergic neurotransmission in very premature-born adults.Human brain mapping · 2023Article
- Repeated Cocaine Intake Differentially Impacts Striatal DInternational journal of molecular sciences · 2023Article
- Gene expression genetics of the striatum of Diversity Outbred mice.Scientific data · 2023Article
- Gene expression genetics of the striatum of Diversity Outbred mice.bioRxiv : the preprint server for biology · 2023Article
- Dopamine DNeurochemical research · 2023Article
- Serotonergic and dopaminergic control of impulsivity in gambling disorder.Addiction biology · 2023Article
- Dopamine increases risky choice while D2 blockade shortens decision time.Experimental brain research · 2022Article
- A Prospective Study on the Relationship between Iron Supplement Intake, Hemoglobin Concentration, and Risk of Parkinsonism.Nutrients · 2022Article
- Adolescent novelty seeking is associated with greater ventral striatal and prefrontal brain response during evaluation of risk and reward.Cognitive, affective & behavioral neuroscience · 2022Article
- Four decades of mapping and quantifying neuroreceptors at workFrontiers in neuroscience · 2022Article
- Single-trial modeling separates multiple overlapping prediction errors during reward processing in human EEG.Communications biology · 2021Article
- Is It Possible to Shift from Down to Top Rank? A Focus on the Mesolimbic Dopaminergic System and Cocaine Abuse.Biomedicines · 2021Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensation seeking is a core personality trait that declines with age in both men and women, as do also both density and availability of the dopamine D(2/3) receptors in striatum and cortical regions. In contrast, novelty seeking at a given age relates inversely to dopamine receptor availability. The simplest explanation of these findings is an inverted-U-shaped correlation between ratings of sensation seeking on the Zuckerman scale and dopamine D(2/3) receptor availability. To test the claim of an inverted-U-shaped relation between ratings of the sensation-seeking personality and measures of dopamine receptor availability, we used PET to record [(11)C]raclopride binding in striatum of 18 healthy men. Here we report that an inverted-U shape significantly matched the receptor availability as a function of the Zuckerman score, with maximum binding potentials observed in the midrange of the scale. The inverted-U shape is consistent with a negative correlation between sensation seeking and the reactivity ("gain") of dopaminergic neurotransmission to dopamine. The correlation reflects Zuckerman scores that are linearly linked to dopamine receptor densities in the striatum but nonlinearly linked to dopamine concentrations. Higher dopamine occupancy and dopamine concentrations explain the motivation that drives afflicted individuals to seek sensations, in agreement with reduced protection against addictive behavior that is characteristic of individuals with low binding potentials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.