ArticleProceedings of the National Academy of Sciences of the United States of America2010
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 59 citations in OpenAlex.
- Enforced MYC expression directs a distinct transcriptional state during plasma cell differentiation.Life science alliance · 2025Article
- Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2.Cell death & disease · 2025Article
- Notch signalling in T cells: bridging tumour immunity and intratumoral cellular crosstalk.Frontiers in immunology · 2025Review
- Metabolic Recycling Enhances Proliferation in MYC-Transformed Lymphoma B Cells.Advanced biology · 2023Article
- Article
- Target gene-independent functions of MYC oncoproteins.Nature reviews. Molecular cell biology · 2020Review
- Crosstalk Between MYC and lncRNAs in Hematological Malignancies.Frontiers in oncology · 2020Review
- Is there a CDKN2A-centric networkOncoTargets and therapy · 2020Review
- Oncogenic MYC amplifies mitotic perturbations.Open biology · 2019Article
- Locating potentially lethal genes using the abnormal distributions of genotypes.Scientific reports · 2019Article
- IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.The Journal of clinical investigation · 2018Article
- Novel TCR-Mediated Mechanisms of Notch Activation and Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- lncRNAs and MYC: An Intricate Relationship.International journal of molecular sciences · 2017Review
- Correspondence: Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα.Nature communications · 2017Article
- Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures.Molecular & cellular proteomics : MCP · 2017Article
- The Quest for Targets Executing MYC-Dependent Cell Transformation.Frontiers in oncology · 2016Review
- MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- MYC and metabolism on the path to cancer.Seminars in cell & developmental biology · 2015Review
- Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells.The EMBO journal · 2015Article
- Taming of the beast: shaping Myc-dependent amplification.Trends in cell biology · 2015Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Ectopic Myc expression plays a key role in human tumorigenesis, and Myc dose-dependent tumorigenesis has been well established in transgenic mice, but the Myc target genes that are dependent on Myc levels have not been well characterized. In this regard, we used the human P493-6 B cells, which have a preneoplastic state dependent on the Epstein-Barr viral EBNA2 protein and a neoplastic state with ectopic inducible Myc, to identify putative ectopic Myc target genes. Among the ectopic targets, JAG2 that encodes a Notch receptor ligand Jagged2, was directly induced by Myc. Inhibition of Notch signaling through RNAi targeting JAG2 or the gamma-secretase Notch inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester (DAPT) preferentially inhibited the neoplastic state in vitro. Furthermore, P493-6 tumorigenesis was inhibited by DAPT in vivo. Ectopic expression of JAG2 did not enhance aerobic cell proliferation, but increased proliferation of hypoxic cells in vitro and significantly increased in vivo tumorigenesis. Furthermore, the expression of Jagged2 in P493-6 tumors often overlapped with regions of hypoxia. These observations suggest that Notch signaling downstream of Myc enables cells to adapt in the tumor hypoxic microenvironment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.