ArticleProceedings of the National Academy of Sciences of the United States of America2010
X chromosome-wide analyses of genomic DNA methylation states and gene expression in male and female neutrophils.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Atlas of imprinted and allele-specific DNA methylation in the human body.Nature communications · 2025Article
- Basic Epigenetic Mechanisms.Sub-cellular biochemistry · 2025Review
- Epigenetics and ultraviolet radiation: Implications for skin ageing and carcinogenesis.Skin health and disease · 2024Review
- Implementation of the Methyl-Seq platform to identify tissue- and sex-specific DNA methylation differences in the rat epigenome.Epigenetics · 2024Article
- MethPhaser: methylation-based long-read haplotype phasing of human genomes.Nature communications · 2024Article
- Shortcut barcoding and early pooling for scalable multiplex single-cell reduced-representation CpG methylation sequencing at single nucleotide resolution.Nucleic acids research · 2023Article
- Sex-biased TGFβ signalling in pulmonary arterial hypertension.Cardiovascular research · 2023Review
- A novel quantitative targeted analysis of X-chromosome inactivation (XCI) using nanopore sequencing.Scientific reports · 2023Article
- Skewed X-Chromosome Inactivation and Compensatory Upregulation of Escape Genes Precludes Major Clinical Symptoms in a Female With a Large Xq Deletion.Frontiers in genetics · 2020Article
- Infrared nanospectroscopic mapping of a single metaphase chromosome.Nucleic acids research · 2019Article
- Human genes escaping X-inactivation revealed by single cell expression data.BMC genomics · 2019Article
- Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation.Nature communications · 2018Article
- Dosage compensation and DNA methylation landscape of the X chromosome in mouse liver.Scientific reports · 2018Article
- Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells.Nucleic acids research · 2017Article
- Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period.Epigenomics · 2017Article
- Recent progress towards understanding the role of DNA methylation in human placental development.Reproduction (Cambridge, England) · 2016Review
- MSP-HTPrimer: a high-throughput primer design tool to improve assay design for DNA methylation analysis in epigenetics.Clinical epigenetics · 2016Article
- Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model.BMC genomics · 2015Article
- Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
The DNA methylation status of human X chromosomes from male and female neutrophils was identified by high-throughput sequencing of HpaII and MspI digested fragments. In the intergenic and intragenic regions on the X chromosome, the sites outside CpG islands were heavily hypermethylated to the same degree in both genders. Nearly half of X chromosome promoters were either hypomethylated or hypermethylated in both females and males. Nearly one third of X chromosome promoters were a mixture of hypomethylated and heterogeneously methylated sites in females and were hypomethylated in males. Thus, a large fraction of genes that are silenced on the inactive X chromosome are hypomethylated in their promoter regions. These genes frequently belong to the evolutionarily younger strata of the X chromosome. The promoters that were hypomethylated at more than two sites contained most of the genes that escaped silencing on the inactive X chromosome. The overall levels of expression of X-linked genes were indistinguishable in females and males, regardless of the methylation state of the inactive X chromosome. Thus, in addition to DNA methylation, other factors are involved in the fine tuning of gene dosage compensation in neutrophils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.