ReviewJournal of the American Society of Nephrology : JASN2010
Integrating human and rodent data to identify the genetic factors involved in chronic kidney disease.
Review in Journal of the American Society of Nephrology : JASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Association of XRCC1 (rs1799782) and XPD (rs13181) gene polymorphisms with renal failure risk in a sample of Iraqi population: a case-control study.Molecular biology reports · 2025Article
- Anti-Inflammatory Effects of Peripheral Dopamine.International journal of molecular sciences · 2023Review
- Using Genetic and Species Diversity to Tackle Kidney Disease.Trends in genetics : TIG · 2020Review
- Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease.Nature medicine · 2018Article
- Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure.JCI insight · 2016Article
- A roadmap for the genetic analysis of renal aging.Aging cell · 2015Review
- Human Urine-Derived Renal Progenitors for Personalized Modeling of Genetic Kidney Disorders.Journal of the American Society of Nephrology : JASN · 2015Article
- MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Genome-wide identification of long noncoding RNAs in rat models of cardiovascular and renal disease.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Genetic architecture of human fibrotic diseases: disease risk and disease progression.Frontiers in pharmacology · 2013Review
- From single nucleotide polymorphism to transcriptional mechanism: a model for FRMD3 in diabetic nephropathy.Diabetes · 2013Article
- Albuminuria is associated with too few glomeruli and too much testosterone.Kidney international · 2013Article
- Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations.American journal of physiology. Renal physiology · 2012Article
- Increased Expression of Rififylin in A < 330 Kb Congenic Strain is Linked to Impaired Endosomal Recycling in Proximal Tubules.Frontiers in genetics · 2012Article
- TGF-alpha mediates genetic susceptibility to chronic kidney disease.Journal of the American Society of Nephrology : JASN · 2011Article
- Mice as a mammalian model for research on the genetics of aging.ILAR journal · 2011Review
- Uncovering genes and regulatory pathways related to urinary albumin excretion.Journal of the American Society of Nephrology : JASN · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The increasing numbers of patients with chronic kidney disease combined with no satisfying interventions for preventing or curing the disease emphasize the need to better understand the genes involved in the initiation and progression of complex renal diseases, their interactions with other host genes, and the environment. Linkage and association studies in human, rat, and mouse have been successful in identifying genetic loci for various disease-related phenotypes but have thus far not been very successful identifying underlying genes. The purpose of this review is to summarize the progress in human, rat, and mouse genetic studies to show the concordance between the loci among the different species. The collective utilization of human and nonhuman mammalian datasets and resources can lead to a more rapid narrowing of disease loci and the subsequent identification of candidate genes. In addition, genes identified through these methods can be further characterized and investigated for interactions using animal models, which is not possible in humans.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.