Evidence map›Paper›PMID 20133179›Full record

ReviewCurrent opinion in microbiology2010

Evolution and phyletic distribution of two-component signal transduction systems.

Kristin Wuichet, Brian J Cantwell, Igor B Zhulin

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 264 citations in OpenAlex.

  1. Article
  2. Microorganisms · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Hemoglobin as an oxygen gasoreceptor.Acta biochimica Polonica · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Light Control in Microbial Systems.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Evaluation of Expanded 2-Aminobenzothiazole Library for Inhibition ofbioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. Polypeptides TargetingJournal of fungi (Basel, Switzerland) · 2023
    Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kristin WuichetDepartment of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
Brian J Cantwell
Igor B Zhulin
University of Tennessee at Knoxville · US

Funding

Computational Genomics of Signal TransductionR01GM072285 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI JOULINE, IGOR B. · 2004 to 2018
$3.2M
NIGMS NIH HHS GM072285NIGMS NIH HHS R01 GM072285
6 · The paper itself

Abstract

Two-component signal transduction systems are abundant in prokaryotes. They enable cells to adjust multiple cellular functions in response to changing environmental conditions. These systems are also found, although in much smaller numbers, in lower eukaryotes and plants, where they appear to control a few very specific functions. Two-component systems have evolved in Bacteria from much simpler one-component systems bringing about the benefit of extracellular versus intracellular sensing. We review reports establishing the origins of two-component systems and documenting their occurrence in major lineages of Life.

Indexed as

Evolution, MolecularPhylogenySignal TransductionArchaeaBacteriaEukaryotaGene Expression RegulationProtein KinasesProteinsProtein KinasesProteins

Identifiers

PMID20133179
PMCPMC3391504
OpenAlexW2102505558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.