ArticleApplied spectroscopy2010
The advantages of an attenuated total internal reflection infrared microspectroscopic imaging approach for kidney biopsy analysis.
Article in Applied spectroscopy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Sample preparation and analysis protocols for the elucidation of structure and chemical distribution in kidney stones.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2024Article
- The Convergence of FTIR and EVs: Emergence Strategy for Non-Invasive Cancer Markers Discovery.Diagnostics (Basel, Switzerland) · 2022Review
- Ligand-Promoted Surface Solubilization of TiOBiomolecules · 2022Article
- Connexin Mutants Cause Cataracts Through Deposition of Apatite.Frontiers in cell and developmental biology · 2022Article
- Multimodal imaging reveals a unique autofluorescence signature of Randall's plaque.Urolithiasis · 2021Article
- Label-free imaging of lipid-rich biological tissues by mid-infrared photoacoustic microscopy.Journal of biomedical optics · 2020Article
- Towards an understanding of the chemo-mechanical influences on kidney stone failure via the material point method.PloS one · 2020Article
- Functional properties of chondrocytes and articular cartilage using optical imaging to scanning probe microscopy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Temporal diabetes-induced biochemical changes in distinctive layers of mouse retina.Scientific reports · 2018Article
- Non-destructive NIR spectral imaging assessment of bone water: Comparison to MRI measurements.Bone · 2017Article
- High-definition Fourier Transform Infrared (FT-IR) spectroscopic imaging of human tissue sections towards improving pathology.Journal of visualized experiments : JoVE · 2015Article
- Differences in infrared spectroscopic data of connective tissues in transflectance and transmittance modes.Analytica chimica acta · 2013Article
- Attenuated total reflectance Fourier-transform infrared spectroscopic imaging for breast histopathology.Vibrational Spectroscopy · 2012Article
- Concentration profiles of collagen and proteoglycan in articular cartilage by Fourier transform infrared imaging and principal component regression.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2012Article
- Chemical visualization of individual chondrocytes in articular cartilage by attenuated-total-reflection Fourier Transform Infrared Microimaging.Biomedical optics express · 2011Article
- Macromolecular concentrations in bovine nasal cartilage by Fourier transform infrared imaging and principal component regression.Applied spectroscopy · 2010Article
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4 authors.
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Abstract
The benefits of an attenuated total reflection Fourier transform infrared (ATR-FTIR) imaging approach for kidney biopsy analysis are described. Biopsy sections collected from kidney-stone formers are analyzed at the initial stages of stone development to provide insights into stone growth and formation. The majority of tissue analysis currently conducted with IR microspectroscopy is performed with a transflection method. The research presented in this manuscript demonstrates that ATR overcomes many of the disadvantages of transflection or transmission measurements for tissue analysis including an elimination of spectral artifacts. When kidney biopsies with small mineral inclusions are analyzed with a transflection approach, specular reflection and the Christiansen effect (anomalous dispersion) can occur, leading to spectral artifacts. Another effect specific to the analysis of mineral inclusions present in kidney biopsies is known as the reststrahlen effect whereby the inclusions become strong reflectors near an absorption band. ATR eliminates these effects by immersing the sample in a high index medium. Additionally, the focused beam size for ATR is decreased by a factor of four when a germanium internal reflection element is used, allowing the acquisition of spectra from small mineral inclusions several micrometers in diameter. If quantitative analysis of small mineral inclusions is ultimately desired, ATR provides the photometrically accurate spectra necessary for quantification.
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