ArticlePsychological medicine2010
Binge eating disorder: a symptom-level investigation of genetic and environmental influences on liability.
Article in Psychological medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- MidbrainbioRxiv : the preprint server for biology · 2026Article
- Shared genetic architecture between eating disorders, mental health conditions, and cardiometabolic diseases: a comprehensive population-wide study across two countries.Nature communications · 2025Article
- The current clinical approach to feeding and eating disorders aimed to increase personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Genetic Predisposition and Severity of Eating Disorders- A Review.CNS & neurological disorders drug targets · 2025Review
- Shared Genetic Influences Between Loss-of-Control Eating and Body Mass Index in Adolescent Twins.The International journal of eating disorders · 2024Article
- Building Confidence in Discussing Genetics With Patients With Eating Disorders and Their Families.Focus (American Psychiatric Publishing) · 2024Article
- The children of parents who receive treatment for binge-eating disorder experience improvements in disordered eating.The International journal of eating disorders · 2024Article
- Genome-wide analysis of a model-derived binge eating disorder phenotype identifies risk loci and implicates iron metabolism.Nature genetics · 2023Article
- Binge Eating Disorder Is a Social Justice Issue: A Cross-Sectional Mixed-Methods Study of Binge Eating Disorder Experts' Opinions.International journal of environmental research and public health · 2022Article
- Article
- Binge eating disorder.Nature reviews. Disease primers · 2022Article
- Genetics of eating disorders in the genome-wide era.Psychological medicine · 2021Review
- A review of binge eating disorder and obesity.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2021Review
- The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics.Clinical therapeutics · 2021Review
- The Binge Eating Genetics Initiative (BEGIN): study protocol.BMC psychiatry · 2020Article
- Maternal Eating Disorders and Eating Disorder Treatment Among Girls in the Growing Up Today Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2019Article
- Article
- Role of eating disorders-related polymorphisms in obesity pathophysiology.Reviews in endocrine & metabolic disorders · 2019Review
- Binge eating symptoms prevalence and relationship with psychosocial factors among female undergraduate students at Palestine Polytechnic University: a cross-sectional study.Journal of eating disorders · 2019Article
- Children of parents with BED have more eating behavior disturbance than children of parents with obesity or healthy weight.The International journal of eating disorders · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
backgroundRecent behavioral genetic studies have emphasized the importance of investigating eating disorders at the level of individual symptoms, rather than as overall diagnoses. We examined the heritability of binge eating disorder (BED) using an item-factor analytic approach, which estimates contributions of additive genetic (A), common environmental (C), and unique environmental (E) influences on liability to BED as well as individual symptoms.
methodParticipants were 614 monozygotic and 410 dizygotic same-sex female twins from the Mid-Atlantic Twin Registry who completed a self-report measure of BED symptoms based upon DSM-IV criteria. Genetic and environmental contributions to BED liability were assessed at the diagnostic and symptom levels, using an item-factor approach.
resultsLiability to BED was moderately heritable; 45% of the variance was due to A, with smaller proportions due to C (13%), and E (42%). Additive genetic effects accounted for 29-43% of the variance in individual items, while only 8-14% was due to C.
conclusionsResults highlight the relevance of examining eating disorders at the symptom level, rather than focusing on aggregate diagnoses.
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