ArticleMolecular cancer2010
Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion.
Article in Molecular cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer.Breast cancer research : BCR · 2015Pooled it
- Review
- Intact glycopeptide analysis of human prostate tissue reveals site-specific heterogeneity of protein glycosylation in prostate cancer.Glycobiology · 2025Article
- Role of Prosaposin and Extracellular Sulfatase Sulf-1 Detection in Pleural Effusions as Diagnostic Biomarkers of Malignant Mesothelioma.Biomedicines · 2022Article
- Impact of Increased FUT8 Expression on the Extracellular Vesicle Proteome in Prostate Cancer Cells.Journal of proteome research · 2020Article
- Comparative proteomic analysis of silica-induced pulmonary fibrosis in rats based on tandem mass tag (TMT) quantitation technology.PloS one · 2020Article
- Article
- REG4 promotes peritoneal metastasis of gastric cancer through GPR37.Oncotarget · 2016Article
- A p-Median approach for predicting drug response in tumour cells.BMC bioinformatics · 2014Article
- The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin.The Journal of biological chemistry · 2014Article
- Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon.Biology and medicine (Aligarh) · 2014Article
- Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT.International journal of biological sciences · 2014Article
- Androgen receptor mutations and polymorphisms in African American prostate cancer.International journal of biological sciences · 2014Article
- Androgen-responsive serum response factor target genes regulate prostate cancer cell migration.Carcinogenesis · 2013Article
- Article
- Article
- Sex-biased genetic effects on gene regulation in humans.Genome research · 2012Article
- New cathepsin D inhibitor library utilizing hydroxyethyl isosteres with cyclic tertiary amines.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2012Article
- Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth.Cancer science · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFactors responsible for invasive and metastatic progression of prostate cancer (PCa) remain largely unknown. Previously, we reported cloning of prosaposin (PSAP) and its genomic amplification and/or overexpression in several androgen-independent metastatic PCa cell lines and lymph node metastases. PSAP is the lysosomal precursor of saposins, which serve as activators for lysosomal hydrolases involved in the degradation of ceramide (Cer) and other sphingolipids.
resultsOur current data show that, in metastatic PCa cells, stable down-modulation of PSAP by RNA-interference via a lysosomal proteolysis-dependent pathway decreased beta1A-integrin expression, its cell-surface clustering, and adhesion to basement membrane proteins; led to disassembly of focal adhesion complex; and decreased phosphorylative activity of focal adhesion kinase and its downstream adaptor molecule, paxillin. Cathepsin D (CathD) expression and proteolytic activity, migration, and invasion were also significantly decreased in PSAP knock-down cells. Transient-transfection studies with beta1A integrin- or CathD-siRNA oligos confirmed the cause and effect relationship between PSAP and CathD or PSAP and Cer-beta1A integrin, regulating PCa cell migration and invasion.
conclusionOur findings suggest that by a coordinated regulation of Cer levels, CathD and beta1A-integrin expression, and attenuation of "inside-out" integrin-signaling pathway, PSAP is involved in PCa invasion and therefore might be used as a molecular target for PCa therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.