ArticleMolecular microbiology2010
The role of the FliK molecular ruler in hook-length control in Salmonella enterica.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Article
- Comparison of Predatory Phenotypes and Genotypes Between Bdellovibrio sp. BIS2 and Bacteriovorax sp. HI3 Isolated From the Same Freshwater Environment.Environmental microbiology · 2026Article
- Bacteria can rotate while body tethered to a solid surface.Biophysical journal · 2025Article
- The impact of the flagellar protein genemSphere · 2025Article
- Structure and Dynamics of the Bacterial Flagellar Motor Complex.Biomolecules · 2024Review
- FlaG competes with FliS-flagellin complexes for access to FlhA in the flagellar T3SS to controlProceedings of the National Academy of Sciences of the United States of America · 2024Article
- FlhE functions as a chaperone to prevent formation of periplasmic flagella in Gram-negative bacteria.Nature communications · 2024Article
- Roles of the components of theFuture microbiology · 2024Review
- Structure, Assembly, and Function of Flagella Responsible for Bacterial Locomotion.EcoSal Plus · 2023Review
- Flagellotropic Bacteriophages: Opportunities and Challenges for Antimicrobial Applications.International journal of molecular sciences · 2022Review
- Article
- The flexible linker of the secreted FliK ruler is required for export switching of the flagellar protein export apparatus.Scientific reports · 2020Article
- FliK-Driven Conformational Rearrangements of FlhA and FlhB Are Required for Export Switching of the Flagellar Protein Export Apparatus.Journal of bacteriology · 2020Article
- TheFrontiers in microbiology · 2020Article
- The flagella of 'Candidatus Liberibacter asiaticus' and its movement in planta.Molecular plant pathology · 2020Article
- Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells.FEMS microbiology letters · 2018Review
- Hook length of the bacterial flagellum is optimized for maximal stability of the flagellar bundle.PLoS biology · 2018Article
- Structure of FlgK reveals the divergence of the bacterial Hook-Filament Junction of Campylobacter.Scientific reports · 2017Article
- Straight and rigid flagellar hook made by insertion of the FlgG specific sequence into FlgE.Scientific reports · 2017Article
- Type Three Secretion System in Attaching and Effacing Pathogens.Frontiers in cellular and infection microbiology · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A molecular ruler, FliK, controls the length of the flagellar hook. FliK measures hook length and catalyses the secretion-substrate specificity switch from rod-hook substrate specificity to late substrate secretion, which includes the filament subunits. Here, we show normal hook-length control and filament assembly in the complete absence of the C-ring thus refuting the previous 'cup' model for hook-length control. Mutants of C-ring components, which are reported to produce short hooks, show a reduced rate of hook-basal body assembly thereby allowing for a premature secretion-substrate specificity switch. Unlike fliK null mutants, hook-length control in an autocleavage-defective mutant of flhB, the protein responsible for the switch to late substrate secretion, is completely abolished. FliK deletion variants that retain the ability to measure hook length are secreted thus demonstrating that FliK directly measures rod-hook length during the secretion process. Finally, we present a unifying model accounting for all published data on hook-length control in which FliK acts as a molecular ruler that takes measurements of rod-hook length while being intermittently secreted during the assembly process of the hook-basal body complex.
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