ArticleEpilepsia2010
Impaired maturation of cortical GABA(A) receptor expression in pediatric epilepsy.
Article in Epilepsia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Reassessing vigabatrin in infantile spasms: clinical risks, mechanistic insights, and future directions.Pediatric research · 2026Article
- Fusion of FDG and FMZ PET Reduces False-Positives in Predicting Epileptogenic Zone.AJNR. American journal of neuroradiology · 2025Article
- Measuring the neurodevelopmental trajectory of excitatory-inhibitory balance via visual gamma oscillations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Knockdown of SIK3 in the CA1 Region can Reduce Seizure Susceptibility in Mice by Inhibiting Decreases in GABAMolecular neurobiology · 2024Article
- Neurodevelopment and early pharmacological interventions in Fragile X Syndrome.Frontiers in neuroscience · 2023Review
- Reduced neurosteroid potentiation of GABAAnnals of clinical and translational neurology · 2020Article
- Challenges in Physiological Phenotyping of hiPSC-Derived Neurons: From 2D Cultures to 3D Brain Organoids.Frontiers in cell and developmental biology · 2020Article
- Mechanisms underlying a critical period of respiratory development in the rat.Respiratory physiology & neurobiology · 2019Review
- Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function.Frontiers in neurology · 2019Review
- Histone deacetylases mediate GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Alterations of Hippocampal Myelin Sheath and Axon Sprouting by Status Convulsion and Regulating Lingo-1 Expression with RNA Interference in Immature and Adult Rats.Neurochemical research · 2018Article
- Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress.Scientific reports · 2017Article
- Behavioral disinhibition and antiepileptic treatment in childhood epilepsy: A retrospective cohort study.Epilepsia open · 2017Article
- Postnatal Erythropoietin Mitigates Impaired Cerebral Cortical Development Following Subplate Loss from Prenatal Hypoxia-Ischemia.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Sex-specific consequences of early life seizures.Neurobiology of disease · 2014Review
- Developmental pharmacology of benzodiazepines under normal and pathological conditions.Epileptic disorders : international epilepsy journal with videotape · 2014Review
- Does epilepsy cause a reversion to immature function?Advances in experimental medicine and biology · 2014Review
- Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A common susceptibility factor of both autism and epilepsy: functional deficiency of GABA A receptors.Journal of autism and developmental disorders · 2013Review
- Functional and structural correlates of the aging brain: relating visual cortex (V1) gamma band responses to age-related structural change.Human brain mapping · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeExpression of the protein subunits that make up the γ-aminobutyric acid (GABA)(A) receptor pentamer is known to change during postnatal brain development in animal models. In the present study, analysis of cortical GABA(A) subunit expression was performed in control human tissue obtained from infancy through adolescence, and was compared to that from similarly aged children with intractable focal epilepsy.
methodsTwenty frozen pediatric control and 25 epileptic neocortical specimens were collected. The membrane fractions were isolated and subjected to quantitative western blot analysis. Subunit expression was correlated with clinical factors including age, pathology, and medication exposure.
resultsIn control cortical samples, α₁ and γ₂ GABA(A) receptor subunits exhibited low expression in infancy, which increased over the first several years of life and then stabilized through adolescence. In contrast, α₄ subunit expression was higher in infants than in older children. The level of the chloride transporter KCC2 increased markedly with age, whereas that of NKCC1 decreased. These patterns were absent in the children with epilepsy, both in those with focal cortical dysplasia and in those with cortical gliosis. Although there was marked variability in GABA(A) receptor subunit expression among the children with epilepsy, identifiable patterns of subunit expression were found in each individual child. DISCUSSION: Maturation of cortical GABA(A) receptor subunit expression continues over the first several years of postnatal human development. Intractable focal epilepsy in children is associated with disruption of this normal developmental pattern. These findings have significant implications for the treatment of children with medications that modulate GABA(A) receptor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.