ReviewExpert opinion on biological therapy2010
Towards organ printing: engineering an intra-organ branched vascular tree.
Review in Expert opinion on biological therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed.
- Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities.Bioactive materials · 2024Review
- Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects.Bioactive materials · 2024Article
- Bioprinting Technologies and Bioinks for Vascular Model Establishment.International journal of molecular sciences · 2023Review
- Advances in Skin Tissue Engineering and Regenerative Medicine.Journal of burn care & research : official publication of the American Burn Association · 2023Article
- Skin Tissue Engineering Advances in Burns: A Brief Introduction to the Past, the Present, and the Future Potential.Journal of burn care & research : official publication of the American Burn Association · 2023Article
- Global hotspots and emerging trends in 3D bioprinting research.Frontiers in bioengineering and biotechnology · 2023Article
- Computational models for generating microvascular structures: Investigations beyond medical imaging resolution.WIREs mechanisms of disease · 2023Review
- Advances in three-dimensional bioprinted stem cell-based tissue engineering for cardiovascular regeneration.Journal of molecular and cellular cardiology · 2022Review
- Three-dimensional printing of clinical scale and personalized calcium phosphate scaffolds for alveolar bone reconstruction.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- Bioengineering Outlook on Cultivated Meat Production.Micromachines · 2022Review
- Optimized 3D Bioprinting Technology Based on Machine Learning: A Review of Recent Trends and Advances.Micromachines · 2022Review
- Air-loaded Gas Vesicle Nanoparticles Promote Cell Growth in Three-dimensional Bioprinted Tissue Constructs.International journal of bioprinting · 2022Article
- Scaffolding Biomaterials for 3D Cultivated Meat: Prospects and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Engineering the multiscale complexity of vascular networks.Nature reviews. Materials · 2022Review
- Engineering a Chemically Defined Hydrogel Bioink for Direct Bioprinting of Microvasculature.Biomacromolecules · 2021Article
- Vascular Tissue Engineering: Challenges and Requirements for an Ideal Large Scale Blood Vessel.Frontiers in bioengineering and biotechnology · 2021Review
- Editorial: 3D Bioprinting of Vascularized Tissues for In Vitro and In Vivo Applications.Frontiers in bioengineering and biotechnology · 2021Article
- Biomaterials for Bioprinting Microvasculature.Chemical reviews · 2020Review
- Solid Organ Bioprinting: Strategies to Achieve Organ Function.Chemical reviews · 2020Review
- Challenges on optimization of 3D-printed bone scaffolds.Biomedical engineering online · 2020Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
importance of the fieldEffective vascularization of thick three-dimensional engineered tissue constructs is a problem in tissue engineering. As in native organs, a tissue-engineered intra-organ vascular tree must be comprised of a network of hierarchically branched vascular segments. Despite this requirement, current tissue-engineering efforts are still focused predominantly on engineering either large-diameter macrovessels or microvascular networks. AREAS COVERED IN THIS REVIEW: We present the emerging concept of organ printing or robotic additive biofabrication of an intra-organ branched vascular tree, based on the ability of vascular tissue spheroids to undergo self-assembly. WHAT THE READER WILL GAIN: The feasibility and challenges of this robotic biofabrication approach to intra-organ vascularization for tissue engineering based on organ-printing technology using self-assembling vascular tissue spheroids including clinically relevantly vascular cell sources are analyzed. TAKE HOME MESSAGE: It is not possible to engineer 3D thick tissue or organ constructs without effective vascularization. An effective intra-organ vascular system cannot be built by the simple connection of large-diameter vessels and microvessels. Successful engineering of functional human organs suitable for surgical implantation will require concomitant engineering of a 'built in' intra-organ branched vascular system. Organ printing enables biofabrication of human organ constructs with a 'built in' intra-organ branched vascular tree.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.