ArticleLangmuir : the ACS journal of surfaces and colloids2010
Zn- and Mg-doped hydroxyapatite nanoparticles for controlled release of protein.
Article in Langmuir : the ACS journal of surfaces and colloids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- New Nanobioceramics Based on Hydroxyapatite for Biomedical Applications: Stability and Properties.Nanomaterials (Basel, Switzerland) · 2025Article
- Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform.Frontiers in bioengineering and biotechnology · 2024Article
- Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel.Biomimetics (Basel, Switzerland) · 2023Article
- Current Development in Biomaterials-Hydroxyapatite and Bioglass for Applications in Biomedical Field: A Review.Journal of functional biomaterials · 2022Review
- Drug Molecular Immobilization and Photofunctionalization of Calcium Phosphates for Exploring Theranostic Functions.Molecules (Basel, Switzerland) · 2022Review
- Strontium doped bioglass incorporated hydrogel-based scaffold for amplified bone tissue regeneration.Scientific reports · 2022Article
- Angio-osteogenic capacity of octacalcium phosphate co-precipitated with copper gluconate in rat calvaria critical-sized defect.Science and technology of advanced materials · 2022Article
- Mechanochemical Preparation, Characterization and Biological Activity of Stable CuS Nanosuspension Capped by Bovine Serum Albumin.Frontiers in chemistry · 2022Article
- Influence of Terbium Ions and Their Concentration on the Photoluminescence Properties of Hydroxyapatite for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Article
- Synthesis and Characterization of Photoluminescent Ce(III) and Ce(IV) Substituted Hydroxyapatite Nanomaterials by Co-Precipitation Method: Cytotoxicity and Biocompatibility Evaluation.Nanomaterials (Basel, Switzerland) · 2021Article
- X-ray Diffraction Analysis and Williamson-Hall Method in USDM Model for Estimating More Accurate Values of Stress-Strain of Unit Cell and Super Cells (2 × 2 × 2) of Hydroxyapatite, Confirmed by Ultrasonic Pulse-Echo Test.Materials (Basel, Switzerland) · 2021Article
- The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers.Clinical oral investigations · 2021Article
- Nature-Derived and Synthetic Additives to poly(ɛ-Caprolactone) Nanofibrous Systems for Biomedicine; an Updated Overview.Frontiers in chemistry · 2021Review
- Ion release from hydroxyapatite and substituted hydroxyapatites in different immersion liquids:Royal Society open science · 2021Article
- A Review of Bioactive Glass/Natural Polymer Composites: State of the Art.Materials (Basel, Switzerland) · 2020Review
- Cryogel biocomposite containing chitosan-gelatin/cerium-zinc doped hydroxyapatite for bone tissue engineering.Saudi journal of biological sciences · 2020Article
- Article
- Rare-earth (GdScientific reports · 2019Article
- Ionic Liquid-Assisted Hydrothermal Synthesis of a Biocompatible Filler for Photo-Curable Dental Composite: From Theory to Experiment.Materials (Basel, Switzerland) · 2019Article
- Synthesis and characterization of Zn-Doped hydroxyapatite: scaffold application, antibacterial and bioactivity studies.Heliyon · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
Bovine serum albumin (BSA) protein incorporated with hydroxyapatite (HA) nanoparticles (NPs) were synthesized by an in situ precipitation process. 2 mol % Zn(2+) and Mg(2+) were used as dopants to synthesize Zn(2+)/Mg(2+)-doped HA-BSA NPs. In our study we used BSA as a model protein. The amount of BSA uptake by doped and undoped HA NPs and subsequent release of BSA from NPs were investigated. Zn-doped HA NPs showed the highest amount of BSA uptake, whereas the amount of BSA loaded in undoped HA NPs was the lowest. A two-stage BSA release profile from doped and undoped HA NPs was observed in phosphate buffer solution (PBS) at pH 7.2 +/- 0.2. The initial burst release was due to the desorption of BSA from the HA surface. The later stage of slow release was controlled by the dissolution of BSA incorporated HA NPs. The BSA release rate from Zn-doped HA NPs was found to be the highest, whereas undoped HA NPs released BSA at the slowest rate. Our study showed that the protein release rate from HA NPs can be controlled by the addition of suitable dopants, and doped HA-based NP systems can be used in bone growth factor and drug release study.
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