ArticleJournal of the American Chemical Society2010
Multiplexed DNA-modified electrodes.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- A Robust Equivalent Circuit Model for DNA-Mediated Electrochemistry.ChemPlusChem · 2026Article
- Quantum bioelectrochemical (QBIOL) software based on point stochastic processes.Communications chemistry · 2025Article
- Developing Microelectrode Arrays for the Point-of-Care Multiplex Detection of Metabolites.Analytical chemistry · 2024Article
- Molecular wrench activity of DNA helicases: Keys to modulation of rapid kinetics in DNA repair.Protein science : a publication of the Protein Society · 2023Article
- Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase.Biochemistry · 2022Article
- The [4Fe4S] Cluster of Yeast DNA Polymerase ε Is Redox Active and Can Undergo DNA-Mediated Signaling.Journal of the American Chemical Society · 2021Article
- Detecting Attomolar DNA-Damaging Anticancer Drug Activity in Cell Lysates with Electrochemical DNA Devices.ACS sensors · 2021Article
- Article
- UvrC Coordinates an OJournal of the American Chemical Society · 2020Article
- A multiplexed, electrochemical interface for gene-circuit-based sensors.Nature chemistry · 2020Article
- Redox Chemistry in the Genome: Emergence of the [4Fe4S] Cofactor in Repair and Replication.Annual review of biochemistry · 2019Review
- Effective Distance for DNA-Mediated Charge Transport between Repair Proteins.ACS central science · 2019Article
- Substrate Binding Regulates Redox Signaling in Human DNA Primase.Journal of the American Chemical Society · 2018Article
- Following anticancer drug activity in cell lysates with DNA devices.Biosensors & bioelectronics · 2018Article
- Nitric Oxide Modulates Endonuclease III Redox Activity by a 800 mV Negative Shift upon [FeJournal of the American Chemical Society · 2018Article
- Sensing DNA through DNA Charge Transport.ACS chemical biology · 2018Review
- A Compass at Weak Magnetic Fields Using Thymine Dimer Repair.ACS central science · 2018Article
- Application of Electrochemical Devices to Characterize the Dynamic Actions of Helicases on DNA.Analytical chemistry · 2018Article
- Electrochemical nucleic acid detection based on parallel structural dsDNA/recombinant azurin hybrid.Biosensors & bioelectronics · 2017Article
- The Oxidation State of [4Fe4S] Clusters Modulates the DNA-Binding Affinity of DNA Repair Proteins.Journal of the American Chemical Society · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report the use of silicon chips with 16 DNA-modified electrodes (DME chips) utilizing DNA-mediated charge transport for multiplexed detection of DNA and DNA-binding protein targets. Four DNA sequences were simultaneously distinguished on a single DME chip with 4-fold redundancy, including one incorporating a single base mismatch. These chips also enabled investigation of the sequence-specific activity of the restriction enzyme Alu1. DME chips supported dense DNA monolayer formation with high reproducibility, as confirmed by statistical comparison to commercially available rod electrodes. The working electrode areas on the chips were reduced to 10 microm in diameter, revealing microelectrode behavior that is beneficial for high sensitivity and rapid kinetic analysis. These results illustrate how DME chips facilitate sensitive and selective detection of DNA and DNA-binding protein targets in a robust and internally standardized multiplexed format.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.