ArticleMolecular biology reports2011
Cloning, chromosomal localization, expression profile and association analysis of the porcine WNT10B gene with backfat thickness.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Sequence characterization and comparative expression profile of buffaloAnimal biotechnology · 2023Article
- Association of genetic variants for FABP3 gene with back fat thickness and intramuscular fat content in pig.Molecular biology reports · 2011Article
- Identification and genetic effects of a novel polymorphism in the distal promoter region of porcine leptin gene.Molecular biology reports · 2011Article
- Molecular characterization, chromosomal localization, expression profile and association analysis with carcass traits of the porcine dickkopf homolog1 gene.Molecular biology reports · 2011Article
- The molecular characterization and associations of porcine cardiomyopathy asssociated 5 (CMYA5) gene with carcass trait and meat quality.Molecular biology reports · 2011Article
- SNPs discovery and CAPS marker conversion in soybean.Molecular biology reports · 2011Article
- Molecular characterization and association analysis of porcine adipose triglyceride lipase (PNPLA2) gene.Molecular biology reports · 2011Article
- Identification of three novel SNPs and association with carcass traits in porcine TNNI1 and TNNI2.Molecular biology reports · 2010Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wingless-type MMTV integration site (Wnt) family encodes secreted glycoproteins that are ligands for the frizzled family of seven-transmembrane receptors and the low density lipoprotein receptor-related protein family of co-receptors. The WNT10B gene inhibits differentiation of preadipocytes in vitro and impairs adipose development in vivo. In the present study, a 1,615-bp cDNA sequence of the porcine WNT10B gene was obtained by RT-PCR. The porcine WNT10B gene was assigned to 5p11-p15 by using the somatic cell hybrid panel (SCHP) and the radiation hybrid (IMpRH) panel. One SNP in the 3'-untranslated region (3'-UTR) was found and association analysis suggested that the SNP was associated with backfat thickness. Semi-quantitative RT-PCR showed that the porcine WNT10B gene was expressed in all tissues examined in 35d and adult pigs and the mRNA expression of WNT10B in fat tissue of Tongcheng pigs was dramatically higher than that in Large White pigs.
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