Evidence map›Paper›PMID 20131006›Full record

ArticleThe international journal of cardiovascular imaging2010

Validation of a new contrast material protocol adapted to body surface area for optimized low-dose CT coronary angiography with prospective ECG-triggering.

Aju P Pazhenkottil, Lars Husmann, Ronny R Buechel, Bernhard A Herzog, René Nkoulou, Irene A Burger, Andrea Vetterli, Ines Valenta, Jelena R Ghadri, Patrick von Schulthess and 1 more

Open access · bronzeAbstract readValidation Study
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Coronary Artery Fistula: A Diagnostic Dilemma.Interventional cardiology (London, England) · 2023
    Review
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  8. Automatic Valve Plane Localization in Myocardial Perfusion SPECT/CT by Machine Learning: Anatomic and Clinical Validation.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Aju P PazhenkottilCardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
Lars Husmann
Ronny R Buechel
Bernhard A Herzog
René Nkoulou
Irene A Burger
Andrea Vetterli
Ines Valenta
Jelena R Ghadri
Patrick von Schulthess
Philipp A Kaufmann
University Hospital of Zurich · CHSwiss Integrative Center for Human Health · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with large total blood volume contrast material (CM) dilution decreases coronary attenuation in CT coronary angiography (CTCA). As increased blood volume is well paralleled by body surface area (BSA) we assessed a BSA-adapted CM protocol to compensate for dilution effects. Low-dose CTCA with prospective ECG-triggering was performed in 80 patients with a BSA-adapted CM bolus ranging 40-105 ml and injection rate ranging 3.5-5.0 ml/s for a BSA of <1.70 to >or=2.5 m(2). Eighty control patients matched for BSA who had previously undergone routine CTCA with a fixed CM protocol of 80 ml at 5 ml/s served as reference group. The average vessel attenuation from the proximal right (RCA) and the left main coronary artery (LMA) was assessed. Correlation of BSA with vessel attenuation was assessed in both groups. BSA-matching of all patients was successful (BSA-adapted group 1.98 +/- 0.15 m(2), range 1.66-2.39 m(2) versus reference group 1.98 +/- 0.17 m(2), range 1.59-2.38 m(2); P = 0.74). Mean CM bolus was significantly smaller in the BSA-adapted versus the reference group (70.9 +/- 14.1 vs. 80.0 +/- 0 ml, P < 0.001). There was no correlation in the BSA-adapted group (r = -0.07, P = 0.53, SEE = 0.15), while coronary attenuation was inversely related to BSA in the reference group (r = -0.59, P < 0.001, SEE = 0.14). We have successfully validated a BSA-adapted contrast material protocol which results in a comparable coronary contrast enhancement independent of individual BSA. This was achieved despite a significant reduction in the overall contrast material amount.

Indexed as

Body Surface AreaAdultAgedAged, 80 and overCase-Control StudiesContrast MediaCoronary AngiographyElectrocardiographyFemaleHumansLinear ModelsMaleMiddle AgedRadiation DosageRetrospective StudiesStatistics, NonparametricContrast MediaiodixanolTriiodobenzoic Acids

Identifiers

PMID20131006
OpenAlexW2032784226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.