ArticleInternational archives of occupational and environmental health2010
Latest status of cadmium accumulation and its effects on kidneys, bone, and erythropoiesis in inhabitants of the formerly cadmium-polluted Jinzu River Basin in Toyama, Japan, after restoration of rice paddies.
Article in International archives of occupational and environmental health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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34 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Association between Environmental Cadmium Exposure and Osteoporosis Risk in Postmenopausal Women: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
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- Mitigating the environmental effects of healthcare: the role of the endocrinologist.Nature reviews. Endocrinology · 2025Review
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- Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases.Biological trace element research · 2024Review
- Environmental Cadmium Exposure Exacerbated Bone Loss in NAFLD Mice.Biological trace element research · 2024Article
- Impact of Occupational Cement Dust Exposure on Hematological Health Parameters: A Cross-Sectional Study.Cureus · 2024Article
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- A suspected case of "itai-itai disease" in a cadmium-polluted area in Akita prefecture, Japan.Environmental health and preventive medicine · 2024Article
- Review
- Recent Aptamer-Based Biosensors for CdBiosensors · 2023Review
- Lower Health Risks of Potentially Toxic Metals after Transplantation of Aquacultural Farmed Mussels from a Polluted Site to Unpolluted Sites: A Biomonitoring Study in the Straits of Johore.Foods (Basel, Switzerland) · 2023Article
- Biomonitoring-Health Risk Nexus of Potentially Toxic Metals onFoods (Basel, Switzerland) · 2023Article
- Estimation of health risks associated with dietary cadmium exposure.Archives of toxicology · 2023Review
- Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue.International journal of environmental research and public health · 2023Review
- The NOAEL Equivalent of Environmental Cadmium Exposure Associated with GFR Reduction and Chronic Kidney Disease.Toxics · 2022Article
- Dose-Response Analysis of the Tubular and Glomerular Effects of Chronic Exposure to Environmental Cadmium.International journal of environmental research and public health · 2022Article
- Review
- Activation of multiple proteolysis systems contributes to acute cadmium cytotoxicity.Molecular and cellular biochemistry · 2022Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe cadmium-polluted Jinzu River Basin in Toyama, Japan, where nephropathy and itai-itai disease were endemic among resident farmers decades ago, has been almost completely restored. The aim of this study is to investigate whether inhabitants there would still exhibit cadmium accumulation and its effects on kidneys, bones, and erythropoiesis.
methodsWe performed a cross-sectional study of 150 subjects from the polluted area and 144 controls from the same prefecture. Participants included female inhabitants from 34 to 74 years of age who underwent examinations to gather anthropometrical and medical information, obtain rice, blood and urine samples, and measure bone mineral density.
resultsCadmium concentration in rice from the polluted area was lower than the level in the control area. Blood and urinary cadmium and urinary β(2)-microglobulin levels were higher in subjects from the polluted area than controls, and the urinary β(2)-microglobulin was independently affected by urinary cadmium. Bone mineral density did not differ between the two areas, but it was affected by renal tubular function in subjects from the polluted area. Serum bone alkaline phosphatase was lower in subjects from the polluted area compared to controls. We detected three cases of cadmium nephropathy among the subjects. One of them suffered from a renal anemia type of itai-itai disease.
conclusionInhabitants in the formerly polluted area still had high cadmium accumulations and showed a characteristic natural history of chronic cadmium toxicity, indicating that the risk remains for developing nephropathy or itai-itai disease in the future.
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