ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2010
The subchondral bone in articular cartilage repair: current problems in the surgical management.
Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Allograft Versus Autograft Osteochondral Transplant for Chondral Defects of the Talus: Systematic Review and Meta-analysis.The American journal of sports medicine · 2022Pooled it
- Material-Assisted Strategies for Osteochondral Defect Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Pooled it
- Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models.Advanced healthcare materials · 2021Pooled it
- Bilayer Scaffolds for Interface Tissue Engineering and Regenerative Medicine: A Systematic Reviews.Advances in experimental medicine and biology · 2021Pooled it
- Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Pooled it
- Two-Year Follow-Up and Remodeling Kinetics of ChonDux Hydrogel for Full-Thickness Cartilage Defect Repair in the Knee.Cartilage · 2020Trial
- Hydrogel implant is as effective as osteochondral autologous transplantation for treating focal cartilage knee injury in 24 months.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Trial
- Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Trial
- The MOBCART (magnetic resonance observation of bone and cartilage repair tissue) add-on score.Insights into imaging · 2026Article
- Article
- Subchondral bone abnormalities in the knee: imaging techniques, regional anatomy, and pathology.Skeletal radiology · 2026Review
- Comparative effectiveness of osteochondral restoration, cell-based regeneration and cell-free implants for knee chondral defects: a systematic review.BMJ open sport & exercise medicine · 2026Article
- Arthroscopic-Assisted Management of Subchondral Bone Marrow Lesions of the Knee.Arthroscopy techniques · 2025Article
- Results of arthroscopic microfracture treatment for traumatic and non-traumatic osteochondral lesions of the talus: a retrospective cohort study.BMC musculoskeletal disorders · 2025Article
- Insights of cartilage imaging in cartilage regeneration.World journal of orthopedics · 2025Review
- Toward Integrative Biomechanical Models of Osteochondral Tissues: A Multilayered Perspective.Bioengineering (Basel, Switzerland) · 2025Review
- Additive manufacturing of patient-specific, biphasic implants with zonal design for regeneration of osteochondral defects-critical evaluation of the work flow from clinical MRI data to implantation.Materials today. Bio · 2025Article
- [Bone marrow edema and osteonecrosis in sport : Relevance, prognosis and therapy].Orthopadie (Heidelberg, Germany) · 2025Review
- ShapeMed-Knee: A Dataset and Neural Shape Model Benchmark for Modeling 3D Femurs.IEEE transactions on medical imaging · 2025Article
- Clinical outcomes of a novel single-stage cartilage repair technique using calcified cartilage zone debridement with hyalofast.PloS one · 2025Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the understanding of interactions between articular cartilage and subchondral bone continues to evolve, increased attention is being directed at treatment options for the entire osteochondral unit, rather than focusing on the articular surface only. It is becoming apparent that without support from an intact subchondral bed, any treatment of the surface chondral lesion is likely to fail. This article reviews issues affecting the entire osteochondral unit, such as subchondral changes after marrow-stimulation techniques and meniscectomy or large osteochondral defects created by prosthetic resurfacing techniques. Also discussed are surgical techniques designed to address these issues, including the use of osteochondral allografts, autologous bone grafting, next generation cell-based implants, as well as strategies after failed subchondral repair and problems specific to the ankle joint. Lastly, since this area remains in constant evolution, the requirements for prospective studies needed to evaluate these emerging technologies will be reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.