Evidence map›Paper›PMID 20130570›Full record

ArticleClinical pharmacology and therapeutics2010

Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials.

C M Baker-Smith, D K Benjamin, R M Califf, M D Murphy, J S Li, P B Smith

Open access · greenAbstract readComparative Study
In one paragraph

Article in Clinical pharmacology and therapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Drug-Induced Cough.Physiological research · 2020
    Review
  4. Should ACE inhibitors and ARBs be used in combination in children?Pediatric nephrology (Berlin, Germany) · 2019
    Article
  5. Article
  6. Pharmacologic Treatment of Pediatric Hypertension.Current hypertension reports · 2016
    Review
  7. Anti-hypertensive drugs in children and adolescents.World journal of cardiology · 2014
    Review
  8. Therapeutic options for the treatment of hypertension in children and adolescents.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2012
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

C M Baker-SmithDepartment of Pediatrics, Duke University, Durham, North Carolina, USA. brian.smith@duke.edu
D K Benjamin
R M Califf
M D Murphy
J S Li
P B Smith
Clinical Research Institute · USDuke University · USUnited States Food and Drug Administration · US

Funding

Pilot Project for the DTMI CRA ProgramUL1RR024128 · NCRR · DUKE UNIVERSITY · PI CALIFF, ROBERT M · 2006 to 2010
$48.1M
North Carolina Collaborative PPRU NetworkU10HD045962 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2004 to 2009
$2.1M
Mentorship of early-career pediatricians in quantitiative methods and therapeuticK24HD058735 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2009 to 2018
$1.5M
PHARMACOKINETICS OF ANTIMICROBIAL AGENTS IN HIGH RISK INFANTSK23HD060040 · NICHD · DUKE UNIVERSITY · PI SMITH, PHILLIP BRIAN · 2009 to 2012
$445k
NCRR NIH HHS 1UL1RR024128-01NCRR NIH HHS UL1 RR024128NICHD NIH HHS 1K23HD060040-01NICHD NIH HHS 1K24HD058735-01NICHD NIH HHS 1U10-HD45962-05NICHD NIH HHS K23 HD060040NICHD NIH HHS K24 HD058735NICHD NIH HHS U10 HD045962
6 · The paper itself

Abstract

The incidence of cough in children receiving antihypertension therapy with angiotensin-converting enzyme inhibitors (ACEis) or angiotensin receptor blockers (ARBs) is unknown. We analyzed patient-level data from eight randomized trials for the treatment of pediatric hypertension, six of them involving ACEis and two involving ARBs. The incidence of cough in children receiving ACEis (reported cough, 3.2%) was similar to that in children receiving ARBs (reported cough, 1.8%) (P = 0.34). Reports of cough were lower in children than in adults.

Indexed as

AdolescentAdultAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersChildCoughFemaleHumansHypertensionIncidenceMalePrevalenceRandomized Controlled Trials as TopicAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor Blockers

Identifiers

PMID20130570
PMCPMC2874085
OpenAlexW2114265396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.