ArticleBiology of reproduction2010
Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.
Article in Biology of reproduction, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the epigenomic network.bioRxiv : the preprint server for biology · 2025Article
- Decoding Müllerian Duct Epithelial Regionalization.Molecular reproduction and development · 2025Review
- Endometrial zinc transporterPNAS nexus · 2025Article
- Hedgehog signaling is required for endometrial remodeling and myometrial homeostasis in the cycling mouse uterus.iScience · 2023Article
- TRIM28 modulates nuclear receptor signaling to regulate uterine function.Nature communications · 2023Article
- A multi-tissue transcriptomic landscape of female mice in estrus and diestrus provides clues for precision medicine.Frontiers in cell and developmental biology · 2022Article
- Increased FOXL2 expression alters uterine structures and functions†.Biology of reproduction · 2020Article
- Uterine Glands: Developmental Biology and Functional Roles in Pregnancy.Endocrine reviews · 2019Review
- SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh.Nature communications · 2018Article
- The ERM family member Merlin is required for endometrial gland morphogenesis.Developmental biology · 2018Article
- Molecular mechanisms of embryonic implantation in mammals: Lessons from the gene manipulation of mice.Reproductive medicine and biology · 2018Review
- Progesterone Receptor Regulation of Uterine Adaptation for Pregnancy.Trends in endocrinology and metabolism: TEM · 2018Review
- A historical review of blastocyst implantation research.Biology of reproduction · 2018Review
- Article
- Forkhead box a2 (FOXA2) is essential for uterine function and fertility.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment.Biology of reproduction · 2017Article
- Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg.Biology of reproduction · 2017Article
- Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.Molecular endocrinology (Baltimore, Md.) · 2016Article
- Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells.Nature communications · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Previous work has identified Indian hedgehog (Ihh) as a major mediator of progesterone signaling during embryo implantation. Ihh acts through its downstream effector smoothened (Smo) to activate the GLI family of transcription factors. In order to gain a better understanding of Ihh action during embryo implantation, we expressed a Cre-recombinase-dependent constitutively activated SMO in the murine uterus using the Pgr(tm2(cre)Lyd) (PR(cre)) mouse model [Pgr(tm2(cre)Lyd+)Gt(ROSA)26Sor(tm1(Smo/EYFP)Amc)(+) (PR(cre/+)SmoM2(+))]. Female PR(cre/+)SmoM2(+) mice were infertile. They exhibited normal serum progesterone levels and normal ovulation, but their ova failed to be fertilized in vivo and their uterus failed to undergo the artificially induced decidual response. Examination of the PR(cre/+)SmoM2(+) uteri revealed numerous features such as uterine hypertrophy, the presence of a stratified luminal epithelial cell layer, a reduced number of uterine glands, and an endometrial stroma that had lost its normal morphologic characteristics. Microarray analysis of 3-mo-old PR(cre/+)SmoM2(+) uteri demonstrated a chondrocytic signature and confirmed that constitutive activation of PR(cre/+)SmoM2(+) increased extracellular matrix production. Thus, constitutive activation of Smo in the mouse uterus alters postnatal uterine differentiation which interferes with early pregnancy. These results provide new insight into the role of Hedgehog signaling during embryo implantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.