ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
The cerebellum harbors a circadian oscillator involved in food anticipation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Effects of leptin deficiency and replacement on cerebellar response to food-related cues.Cerebellum (London, England) · 2013Trial
- Short-term plasticity of gray matter associated with leptin deficiency and replacement.The Journal of clinical endocrinology and metabolism · 2011Trial
- A population of dopaminergic neurons in the substantia nigra is required for food-anticipatory activity.Current biology : CB · 2026Article
- Defining Clock Neurons Within Distributed Circadian Circuits Through Multiscale Technologies.Journal of biological rhythms · 2026Review
- Predictive and instructive cerebellar encoding of dopamine reward drives motivated behavior.Nature neuroscience · 2026Article
- Genetic Identification of Dopamine Neurons Required for Circadian Food Anticipatory Activity in Mice.bioRxiv : the preprint server for biology · 2026Article
- Elucidation of daily timed-palatable meal-anticipatory activity in the circadian system of mice.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Social context suppresses food anticipatory activity and associated thermoregulation in mice.PloS one · 2026Article
- Circadian rhythms are disrupted in patients and preclinical models of Machado-Joseph disease.Brain : a journal of neurology · 2025Article
- Autism Spectrum Disorder: The Cerebellum, Genes, and Pathways.Neurology international · 2025Review
- Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025Review
- Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024Review
- Sweetened caffeine drinking revealed behavioral rhythm independent of the central circadian clock in male mice.NPJ science of food · 2024Article
- Cerebellar Functions Beyond Movement and Learning.Annual review of neuroscience · 2024Review
- Purkinje cell dysfunction causes disrupted sleep in ataxic mice.Disease models & mechanisms · 2024Article
- The Cerebellar Response to Visual Portion Size Cues Is Associated with the Portion Size Effect in Children.Nutrients · 2024Article
- Linking the cerebellum to Parkinson disease: an update.Nature reviews. Neurology · 2023Review
- Cerebellar Prediction and Feeding Behaviour.Cerebellum (London, England) · 2023Review
- Syndecan-4 as a genetic determinant of the metabolic syndrome.Diabetology & metabolic syndrome · 2023Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum participates in motor coordination as well as in numerous cerebral processes, including temporal discrimination. Animals can predict daily timing of food availability, as manifested by food-anticipatory activity under restricted feeding. By studying ex vivo clock gene expression by in situ hybridization and recording in vitro Per1-luciferase bioluminescence, we report that the cerebellum contains a circadian oscillator sensitive to feeding cues (i.e., whose clock gene oscillations are shifted in response to restricted feeding). Food-anticipatory activity was markedly reduced in mice injected intracerebroventricularly with an immunotoxin that depletes Purkinje cells (i.e., OX7-saporin). Mice bearing the hotfoot mutation (i.e., Grid2(ho/ho)) have impaired cerebellar circuitry and mild ataxic phenotype. Grid2(ho/ho) mice fed ad libitum showed regular behavioral rhythms and day-night variations of clock gene expression in the hypothalamus and cerebellum. When challenged with restricted feeding, however, Grid2(ho/ho) mice did not show any food-anticipatory rhythms, nor timed feeding-induced changes in cerebellar clock gene expression. In hypothalamic arcuate and dorsomedial nuclei, however, shifts in Per1 expression in response to restricted feeding were similar in cerebellar mutant and wild-type mice. Furthermore, plasma corticosterone and metabolites before mealtime did not differ between cerebellar mutant and wild-type mice. Together, these data define a role for the cerebellum in the circadian timing network and indicate that the cerebellar oscillator is required for anticipation of mealtime.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.