Evidence map›Paper›PMID 20130055›Full record

ArticleJournal of virology2010

Species-specific inhibition of foamy viruses from South American monkeys by New World Monkey TRIM5{alpha} proteins.

Beatriz Pacheco, Andrés Finzi, Kathleen McGee-Estrada, Joseph Sodroski

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Beatriz PachecoDana-Farber Cancer Institute, 44 Binney Street, CLS 1010, Boston, MA 02115, USA.
Andrés Finzi
Kathleen McGee-Estrada
Joseph Sodroski
Harvard University · US

Funding

Antiretroviral Activity of TRIM5alphaR01AI063987 · NIAID · DANA-FARBER CANCER INSTITUTE · PI SODROSKI, JOSEPH G · 2005 to 2014
$4.2M
Structure of the Retroviral Restriction Factor, TRIM5alphaR21AI076094 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2007 to 2008
$463k
NIAID NIH HHS AI 06354NIAID NIH HHS AI 063987NIAID NIH HHS AI 076094NIAID NIH HHS R01 AI063987NIAID NIH HHS R21 AI076094
6 · The paper itself

Abstract

Foamy virus evolution closely parallels that of the host species, indicating virus-host coadaptation. We studied simian foamy viruses (SFVs) from common marmosets, spider monkeys, and squirrel monkeys, New World monkey (NWM) species that share geographic ranges. The TRIM5alpha protein from each of these NWM species inhibited the replication of at least one of the SFVs associated with the other two species but did not affect the replication of its own SFV. Thus, TRIM5alpha has potentially shaped the evolution of SFVs in NWM hosts. Conversely, SFVs may have influenced the evolution of TRIM5 variants in New World primates.

Indexed as

AnimalsAtelinaeCallithrixCells, CulturedMolecular Sequence DataProteinsSaimiriSequence Analysis, DNASpumavirusUbiquitin-Protein LigasesVirus ReplicationProteinsTRIM5(alpha) protein, rhesus monkeyUbiquitin-Protein Ligases

Identifiers

PMID20130055
PMCPMC2849481
OpenAlexW2143829480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.