ArticleProceedings. Biological sciences2010
Long-term evolution of antigen repertoires among carried meningococci.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 36 citations in OpenAlex.
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- Variation among strains of Borrelia burgdorferi in host tissue abundance and lifetime transmission determine the population strain structure in nature.PLoS pathogens · 2023Article
- Diversification in immunogenicity genes caused by selective pressures in invasive meningococci.Microbial genomics · 2020Article
- Diversity of HLA Class I and Class II blocks and conserved extended haplotypes in Lacandon Mayans.Scientific reports · 2020Article
- Parallel sequencing of porA reveals a complex pattern of Campylobacter genotypes that differs between broiler and broiler breeder chickens.Scientific reports · 2019Article
- Reverse immunodynamics: a new method for identifying targets of protective immunity.Scientific reports · 2019Article
- Models of immune selection for multi-locus antigenic diversity of pathogens.Nature reviews. Immunology · 2019Review
- Frequent capsule switching in 'ultra-virulent' meningococci - Are we ready for a serogroup B ST-11 complex outbreak?The Journal of infection · 2017Article
- Fitness estimates from experimental infections predict the long-term strain structure of a vector-borne pathogen in the field.Scientific reports · 2017Article
- Metabolic shift in the emergence of hyperinvasive pandemic meningococcal lineages.Scientific reports · 2017Article
- Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- MANTIS: an R package that simulates multilocus models of pathogen evolution.BMC bioinformatics · 2015Article
- Contrasting within- and between-host immune selection shapes Neisseria Opa repertoires.Scientific reports · 2014Article
- Pathogen selection drives nonoverlapping associations between HLA loci.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Genetic distribution of noncapsular meningococcal group B vaccine antigens in Neisseria lactamica.Clinical and vaccine immunology : CVI · 2013Article
- The impact of protein-conjugate polysaccharide vaccines: an endgame for meningitis?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis.PloS one · 2013Article
- An analysis of the sequence variability of meningococcal fHbp, NadA and NHBA over a 50-year period in the Netherlands.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Most studies of bacterial pathogen populations have been based on isolates collected from individuals with disease, or their contacts, over short time periods. For commensal organisms that occasionally cause disease, such as Neisseria meningitidis, however, the analysis of isolates from long-term asymptomatic carriage is necessary to elucidate their evolution and population structure. Here, we use mathematical models to analyse the structuring and dynamics of three vaccine-candidate antigens among carried meningococcal isolates collected over nearly 30 years in the Czech Republic. The data indicate that stable combinations of antigenic alleles were maintained over this time period despite evidence for high rates of recombination, consistent with theoretical models in which strong immune selection can maintain non-overlapping combinations of antigenic determinants in the presence of recombination. We contrast this antigenic structure with the overlapping but relatively stable combinations of the housekeeping genes observed among the same isolates, and use a novel network approach to visualize these relationships.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.