ReviewProceedings. Biological sciences2010
Experimental genomics of fitness in yeast.
Review in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The fitness trade-off between growth and stress resistance determines the phenotypic landscape.BMC biology · 2024Article
- Single nucleotide polymorphisms associated with wine fermentation and adaptation to nitrogen limitation in wild and domesticated yeast strains.Biological research · 2023Article
- Predicting evolutionary outcomes through the probability of accessing sequence variants.Science advances · 2023Article
- MarkedG3 (Bethesda, Md.) · 2020Article
- Predicting microbial growth in a mixed culture from growth curve data.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Global study of holistic morphological effectors in the budding yeast Saccharomyces cerevisiae.BMC genomics · 2018Article
- Identification of the fitness determinants of budding yeast on a natural substrate.The ISME journal · 2017Article
- Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins.PloS one · 2017Article
- Accelerating Mutational Load Is Not Due to Synergistic Epistasis or Mutator Alleles in Mutation Accumulation Lines of Yeast.Genetics · 2016Article
- Costs of CRISPR-Cas-mediated resistance in Streptococcus thermophilus.Proceedings. Biological sciences · 2015Article
- Maintenance of Quantitative Genetic Variance Under Partial Self-Fertilization, with Implications for Evolution of Selfing.Genetics · 2015Article
- The interaction of Saccharomyces paradoxus with its natural competitors on oak bark.Molecular ecology · 2015Article
- Effects of new mutations on fitness: insights from models and data.Annals of the New York Academy of Sciences · 2014Review
- The fates of mutant lineages and the distribution of fitness effects of beneficial mutations in laboratory budding yeast populations.Genetics · 2014Article
- Measuring competitive fitness in dynamic environments.The journal of physical chemistry. B · 2013Article
- Evolutionary rescue and the limits of adaptation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Ontology-based cross-species integration and analysis of Saccharomyces cerevisiae phenotypes.Journal of biomedical semantics · 2012Article
- Review
- Epistasis for growth rate and total metabolic flux in yeast.PloS one · 2012Article
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The set of single-gene deletions in yeast can be used to evaluate the effect of mutation on fitness over the whole genome. The measurement of growth in pure culture or relative growth in mixtures has confirmed that most deletions have little effect in laboratory culture. Moreover, there is a sharp distinction between lethality and a very mild impairment of growth, with very few intermediate cases. Different components of fitness, such as growth rate and yield, are positively correlated. Growth is also positively correlated across environments, although new conditions of growth usually identify a few conditionally impaired strains. Double mutants on average show alleviating epistasis, although a few per cent of combinations are synthetic lethal. The properties of the yeast deletion set provide us with the first genome-wide account of fitness, although transferring these conclusions to the field is a task for the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.