ArticleCancer cell2010
Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis.
Article in Cancer cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed, 129 citations in OpenAlex.
- N-methyl-D-aspartate receptor blockers attenuate bleomycin-induced pulmonary fibrosis by inhibiting endogenous mesenchymal stem cells senescence.Annals of translational medicine · 2022Article
- Targeting CDK4 and CDK6 in cancer.Nature reviews. Cancer · 2022Review
- ΔN63 suppresses the ability of pregnancy-identified mammary epithelial cells (PIMECs) to drive HER2-positive breast cancer.Cell death & disease · 2021Article
- TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity.Oncogenesis · 2021Article
- PPARα-Selective Antagonist GW6471 Inhibits Cell Growth in Breast Cancer Stem Cells Inducing Energy Imbalance and Metabolic Stress.Biomedicines · 2021Article
- Oncogenic miR-20b-5p contributes to malignant behaviors of breast cancer stem cells by bidirectionally regulating CCND1 and E2F1.BMC cancer · 2020Article
- LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase.Neoplasia (New York, N.Y.) · 2020Article
- Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1.Nature metabolism · 2020Article
- Strategies for Increasing the Effectiveness of Aromatase Inhibitors in Locally Advanced Breast Cancer: An Evidence-Based Review on Current Options.Cancer management and research · 2020Review
- Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology.Expert review of anticancer therapy · 2019Review
- p21CIP1 Promotes Mammary Cancer-Initiating Cells via Activation of Wnt/TCF1/CyclinD1 Signaling.Molecular cancer research : MCR · 2019Article
- A method of producing genetically manipulated mouse mammary gland.Breast cancer research : BCR · 2019Article
- Overexpression of miR-489 derails mammary hierarchy structure and inhibits HER2/neu-induced tumorigenesis.Oncogene · 2019Article
- Inhibition of Sirt6 suppresses tumor growth by inducing G1/S phase arrest in renal cancer cells.International journal of clinical and experimental pathology · 2019Article
- Is ctDNA the Road Map to the Landscape of the Clonal Mutational Evolution in Drug Resistance? Lessons from the PALOMA-3 Study and Implications for Precision Medicine.Cancer discovery · 2018Article
- CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest.Trends in cell biology · 2018Review
- The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division.Science signaling · 2018Article
- CDK4/6 inhibition in breast cancer: current practice and future directions.Therapeutic advances in medical oncology · 2018Review
- Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.Neoplasia (New York, N.Y.) · 2017Article
- DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle.Journal of cellular and molecular medicine · 2017Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Transplantation studies have demonstrated the existence of mammary progenitor cells with the ability to self-renew and regenerate a functional mammary gland. Although these progenitors are the likely targets for oncogenic transformation, correlating progenitor populations with certain oncogenic stimuli has been difficult. Cyclin D1 is required for lobuloalveolar development during pregnancy and lactation as well as MMTV-ErbB2- but not MMTV-Wnt1-mediated tumorigenesis. Using a kinase-deficient cyclin D1 mouse, we identified two functional mammary progenitor cell populations, one of which is the target of MMTV-ErbB2. Moreover, cyclin D1 activity is required for the self-renewal and differentiation of mammary progenitors because its abrogation leads to a failure to maintain the mammary epithelial regenerative potential and also results in defects in luminal lineage differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.