ArticleGenome biology2010
Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life.Ageing research reviews · 2023Review
- Improving Analysis and Annotation of Microarray Data with Protein Interactions.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Why imaging data alone is not enough: AI-based integration of imaging, omics, and clinical data.European journal of nuclear medicine and molecular imaging · 2019Review
- pathfindR: An R Package for Comprehensive Identification of Enriched Pathways in Omics Data Through Active Subnetworks.Frontiers in genetics · 2019Article
- Classifying mild traumatic brain injuries with functional network analysis.BMC systems biology · 2018Article
- A review of supervised machine learning applied to ageing research.Biogerontology · 2017Review
- Comparative network analysis via differential graphlet communities.Proteomics · 2015Article
- Integrative approaches for finding modular structure in biological networks.Nature reviews. Genetics · 2013Review
- Distinctive topology of age-associated epigenetic drift in the human interactome.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- An integer linear programming approach for finding deregulated subgraphs in regulatory networks.Nucleic acids research · 2012Article
- Article
- Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.PLoS genetics · 2012Article
- Integrative computational biology for cancer research.Human genetics · 2011Review
- MicroRNA predictors of longevity in Caenorhabditis elegans.PLoS genetics · 2011Article
- Optimally discriminative subnetwork markers predict response to chemotherapy.Bioinformatics (Oxford, England) · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A central goal of biogerontology is to identify robust gene-expression biomarkers of aging. Here we develop a method where the biomarkers are networks of genes selected based on age-dependent activity and a graph-theoretic property called modularity. Tested on Caenorhabditis elegans, our algorithm yields better biomarkers than previous methods - they are more conserved across studies and better predictors of age. We apply these modular biomarkers to assign novel aging-related functions to poorly characterized longevity genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.