ArticleGenome biology2010
Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats.
Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol.Biomedicines · 2022Article
- Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction.Frontiers in neuroscience · 2022Article
- Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules.Biomolecules · 2020Review
- Estrogen-Dependent Upregulation ofFrontiers in genetics · 2018Article
- Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.Journal of genetics and genomics = Yi chuan xue bao · 2016Article
- A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co-expression Network in Genetic Vulnerability to Alcohol Withdrawal.Frontiers in genetics · 2016Article
- DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesions.American journal of respiratory cell and molecular biology · 2015Article
- An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures.Journal of anxiety disorders · 2015Article
- XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Genetic risk prediction and neurobiological understanding of alcoholism.Translational psychiatry · 2014Article
- Reduced expression of α-synuclein in alcoholic brain: influence of SNCA-Rep1 genotype.Addiction biology · 2014Article
- Gene expression in the addicted brain.International review of neurobiology · 2014Review
- Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders.Frontiers in neuroscience · 2014Review
- Loss of metabotropic glutamate receptor 2 escalates alcohol consumption.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2.Alcohol (Fayetteville, N.Y.) · 2013Article
- Genetically selected alcohol preferring rats to model human alcoholism.Current topics in behavioral neurosciences · 2013Article
- Relationship between differential hepatic microRNA expression and decreased hepatic cytochrome P450 3A activity in cirrhosis.PloS one · 2013Article
- Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption.PloS one · 2013Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundSelectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats differ greatly in alcohol preference, in part due to a highly significant quantitative trait locus (QTL) on chromosome 4. Alcohol consumption scores of reciprocal chromosome 4 congenic strains NP.P and P.NP correlated with the introgressed interval. The goal of this study was to identify candidate genes that may influence alcohol consumption by comparing gene expression in five brain regions of alcohol-naïve inbred alcohol-preferring and P.NP congenic rats: amygdala, nucleus accumbens, hippocampus, caudate putamen, and frontal cortex.
resultsWithin the QTL region, 104 cis-regulated probe sets were differentially expressed in more than one region, and an additional 53 were differentially expressed in a single region. Fewer trans-regulated probe sets were detected, and most differed in only one region. Analysis of the average expression values across the 5 brain regions yielded 141 differentially expressed cis-regulated probe sets and 206 trans-regulated probe sets. Comparing the present results from inbred alcohol-preferring vs. congenic P.NP rats to earlier results from the reciprocal congenic NP.P vs. inbred alcohol-nonpreferring rats demonstrated that 74 cis-regulated probe sets were differentially expressed in the same direction and with a consistent magnitude of difference in at least one brain region.
conclusionsCis-regulated candidate genes for alcohol consumption that lie within the chromosome 4 QTL were identified and confirmed by consistent results in two independent experiments with reciprocal congenic rats. These genes are strong candidates for affecting alcohol preference in the inbred alcohol-preferring and inbred alcohol-nonpreferring rats.
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